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MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview
- Source :
- European journal of endocrinology. 176(6)
- Publication Year :
- 2016
-
Abstract
- Aging and its underlying pathophysiological background has always attracted the attention of the scientific society. Defined as the gradual, time-dependent, heterogeneous decline of physiological functions, aging is orchestrated by a plethora of molecular mechanisms, which vividly interact to alter body homeostasis. The ability of an organism to adjust to these alterations, in conjunction with the dynamic effect of various environmental stimuli across lifespan, promotes longevity, frailty or disease. Endocrine function undergoes major changes during aging, as well. Specifically, alterations in hormonal networks and concomitant hormonal deficits/excess, augmented by poor sensitivity of tissues to their action, take place. As hypothalamic–pituitary unit is the central regulator of crucial body functions, these alterations can be translated in significant clinical sequelae that can impair the quality of life and promote frailty and disease. Delineating the hormonal signaling alterations that occur across lifespan and exploring possible remedial interventions could possibly help us improve the quality of life of the elderly and promote longevity.
- Subjects :
- 0301 basic medicine
Male
Aging
Endocrinology, Diabetes and Metabolism
Regulator
Thyroid Gland
Disease
Hyperthyroidism
Antioxidants
0302 clinical medicine
Endocrinology
Insulin-Secreting Cells
Testosterone
Precision Medicine
Ovarian Reserve
Organism
media_common
Feedback, Physiological
Stem Cells
Estrogen Replacement Therapy
Longevity
Fertility Preservation
General Medicine
Water-Electrolyte Balance
3. Good health
Circadian Rhythm
Androgens
Female
Menopause
medicine.medical_specialty
Hypothalamo-Hypophyseal System
Diet therapy
Hormone Replacement Therapy
media_common.quotation_subject
030209 endocrinology & metabolism
Endocrine System
03 medical and health sciences
Adjuvants, Immunologic
Hypothyroidism
Internal medicine
medicine
Endocrine system
Humans
Hypoglycemic Agents
Scientific society
business.industry
Hypogonadism
Dehydroepiandrosterone
Oxidative Stress
030104 developmental biology
Diabetes Mellitus, Type 2
Quality of Life
business
Hyperandrogenism
Homeostasis
Gonadotropins
Diet Therapy
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 1479683X
- Volume :
- 176
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- European journal of endocrinology
- Accession number :
- edsair.doi.dedup.....6bb30cb70c9e96862048c63bff23b801