Linezolid for the treatment of multidrug-resistant tuberculosis

Authors :: Jesús Fortún
Pilar Martín-Dávila
E Gómez-Mampaso
Marta Tato
Javier Cobo
Ma Jesús Pérez-Elías
Enrique Navas
Santiago Moreno
Elia Gómez G. de la Pedrosa
Source :: The Journal of antimicrobial chemotherapy. 56(1)
Publication Year :: 2005
Abstract: OBJECTIVES In vitro studies have shown good activity of linezolid against Mycobacterium tuberculosis, including multidrug-resistant strains. However, clinical experience with linezolid in tuberculosis is scarce. METHODS We report our clinical experience with five consecutive patients with multidrug-resistant tuberculosis infection treated with combination regimens that included linezolid. RESULTS Two patients had multidrug-resistant Mycobacterium bovis infection, with resistance to 12 antituberculous agents (one of them with HIV co-infection and

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