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Mechanical Frequency Tuning by Sensory Hair Cells, the Receptors and Amplifiers of the Inner Ear
- Source :
- Annual Review of Condensed Matter Physics, Annual Review of Condensed Matter Physics, Annual Reviews 2021, 12 (1), ⟨10.1146/annurev-conmatphys-061020-053041⟩
- Publication Year :
- 2021
- Publisher :
- Annual Reviews, 2021.
-
Abstract
- International audience; We recognize sounds by analyzing their frequency content. Different frequency components evoke distinct mechanical waves that each travel within the hearing organ, or cochlea, to a frequency-specific place. These signals are detected by hair cells, the ear's sensory receptors, in response to vibrations of mechanically sensitive antennas termed hair bundles. An active process enhances the sensitivity, sharpens the frequency tuning, and broadens the dynamic range of hair cells through several mechanisms, including active hair-bundle motility. A dynamic interplay between negative stiffness mediated by ion channels' gating forces and delayed force feedback owing to myosin motors and channel reclosure by calcium ions brings the hair bundle to the vicinity of an oscillatory instability-a Hopf bifurcation. Operation near a Hopf bifurcation provides nonlinear generic features that are characteristic of hearing. Multiple gradients at molecular, cellular, and supercellular scales tune hair cells to characteristic frequencies that cover our auditory range.
- Subjects :
- 0301 basic medicine
[PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph]
Quantitative Biology::Tissues and Organs
cochlea
auditory system
Quantitative Biology::Subcellular Processes
03 medical and health sciences
0302 clinical medicine
otorhinolaryngologic diseases
medicine
Auditory system
traveling wave
General Materials Science
Inner ear
Hopf bifurcation
[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organs
Receptor
Cochlea
Physics
Amplifier
hair bundle
Sensory hair
transduction
Condensed Matter Physics
030104 developmental biology
medicine.anatomical_structure
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
sense organs
Mechanical wave
Transduction (physiology)
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 19475462 and 19475454
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Annual Review of Condensed Matter Physics
- Accession number :
- edsair.doi.dedup.....6b96cd88750999ccaeacad0798e2ba84