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Does plasma thiol and disulphide be a new marker for prostate cancer in prostate-specific antigen level between 10 and 20 ng/ml?
- Source :
- The Aging Male. 23:860-864
- Publication Year :
- 2019
- Publisher :
- Informa UK Limited, 2019.
-
Abstract
- We aimed to evaluate plasma thiol and disulphide levels as an additional marker to prostate specific antigen (PSA) in the diagnosis of prostate cancer (PCa).Between March 2017 and January 2018 prospective study was conducted among patients with PSA levels of 2.5-20 ng/mL without suspicion of malignancy in rectal examination and who underwent prostate needle biopsy. Patients were divided into two groups according to PSA level as 2.5-10 ng/mL (Group 1) and 10.01-20 ng/mL (Group 2). Diagnostic efficacy of thiol, disulphide and PSA levels were measured by ROC analysis.A total of 76 patients were included in the study. There were 49 patients in group 1 and 27 patients in group 2. There was no significant difference between two groups in terms of PSA density and prostate size. In Group 1, area under curve (AUC) was higher in PSA than other parameters with statistically significant difference (We think that plasma thiol test may be used in diagnosis of prostate cancer while PSA levels between 10 to 20 ng/mL. However, further studies are required.
- Subjects :
- Male
chemistry.chemical_classification
business.industry
Biopsy
030232 urology & nephrology
Prostatic Neoplasms
030209 endocrinology & metabolism
Prostate-Specific Antigen
urologic and male genital diseases
medicine.disease
03 medical and health sciences
Prostate-specific antigen
Prostate cancer
0302 clinical medicine
ROC Curve
chemistry
Thiol
Cancer research
Humans
Medicine
Disulfides
Prospective Studies
Sulfhydryl Compounds
Geriatrics and Gerontology
business
Subjects
Details
- ISSN :
- 14730790 and 13685538
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- The Aging Male
- Accession number :
- edsair.doi.dedup.....6b91f9d4e7e125601459715e56cd2d6c