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Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy
- Source :
- Epilepsia Open, Epilepsia Open, 4(3), 420. Wiley-Blackwell Publishing Ltd, Epilepsia Open, 4(3), 420-430. Wiley-Blackwell, Epilepsia Open, 4 (3, EPILEPSIA OPEN, Epilepsia Open, Vol 4, Iss 3, Pp 420-430 (2019), Epilepsia Open, 0(0). (2019).
- Publication Year :
- 2019
- Publisher :
- John Wiley and Sons Inc., 2019.
-
Abstract
- Objective: To study the effectiveness and tolerability of antiepileptic drugs (AEDs) commonly used in juvenile myoclonic epilepsy (JME). Methods: People with JME were identified from a large database of individuals with epilepsy, which includes detailed retrospective information on AED use. We assessed secular changes in AED use and calculated rates of response (12-month seizure freedom) and adverse drug reactions (ADRs) for the five most common AEDs. Retention was modeled with a Cox proportional hazards model. We compared valproate use between males and females. Results: We included 305 people with 688 AED trials of valproate, lamotrigine, levetiracetam, carbamazepine, and topiramate. Valproate and carbamazepine were most often prescribed as the first AED. The response rate to valproate was highest among the five AEDs (42.7%), and significantly higher than response rates for lamotrigine, carbamazepine, and topiramate; the difference to the response rate to levetiracetam (37.1%) was not significant. The rates of ADRs were highest for topiramate (45.5%) and valproate (37.5%). Commonest ADRs included weight change, lethargy, and tremor. In the Cox proportional hazards model, later start year (1.10 [1.08-1.13], P<br />SCOPUS: ar.j<br />info:eu-repo/semantics/published
- Subjects :
- Topiramate
Pediatrics
medicine.medical_specialty
Neurology [D14] [Human health sciences]
seizure
adverse drug reaction
Clinical Neurology
Lamotrigine
lcsh:RC346-429
03 medical and health sciences
Epilepsy
0302 clinical medicine
Journal Article
medicine
030212 general & internal medicine
EpiPGX Consortium
tolerability
lcsh:Neurology. Diseases of the nervous system
seizures
adverse drug reactions
Neurologie [D14] [Sciences de la santé humaine]
business.industry
Weight change
Généralités
Carbamazepine
medicine.disease
3. Good health
valproate
Neurology
Tolerability
Full‐length Original Research
Neurology (clinical)
Levetiracetam
Juvenile myoclonic epilepsy
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 24709239
- Volume :
- 4
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Epilepsia Open
- Accession number :
- edsair.doi.dedup.....6b7e0fce4bbd4be523bd2afab4c4cd80