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Post-meiotic cell mediation of behavior in progeny of male rats treated with cyclophosphamide
- Source :
- Mutation Research Letters. 119:185-190
- Publication Year :
- 1983
- Publisher :
- Elsevier BV, 1983.
-
Abstract
- Transmission of the effects of paternal pre-fertilization exposure to a genotoxic drug being manifested in the F1 progeny is well established using the traditional rodent dominant lethal protocol [7]. More recently, the induction of genotoxic effects in the F1 progeny following chronic paternal exposure prior to fertilization has been described in rats using behavioral testing as an endpoint [1]. In our initial study, male F344 adult rats were treated chronically with 10 mg/kg cyclophosphamide (CP) or saline for 5 weeks (5 days of daily treatment and 2 days of rest). The present study describes the behavior of progeny whose fathers were treated with a single intraperitoneal injection of 10 mg/kg CP and mated at different times post-injection. This design showed that post-meiotic germ cells are the most sensitive to the effects of CP as seen by behavioral testing of the F1 progeny.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Behavior, Animal
Cyclophosphamide
Rodent
medicine.medical_treatment
Intraperitoneal injection
General Medicine
Biology
Rats
Meiosis
Paternal Exposure
Human fertilization
Endocrinology
Internal medicine
biology.animal
Male rats
medicine
Meiotic cell
Animals
Spermatogenesis
Saline
medicine.drug
Subjects
Details
- ISSN :
- 01657992
- Volume :
- 119
- Database :
- OpenAIRE
- Journal :
- Mutation Research Letters
- Accession number :
- edsair.doi.dedup.....6b6ed49e5ada68f7c38ae9308364b106