Interaction of human phospholipid scramblase 1 with cholesterol via CRAC motif is essential for functional regulation and subcellular localization

Authors :: Muhasin, Koyiloth
Sathyanarayana N, Gummadi
Source :: International Journal of Biological Macromolecules. 209:850-857
Publication Year :: 2022
Publisher :: Elsevier BV, 2022.
Abstract: Human phospholipid scramblase 1 (hPLSCR1) possesses a putative cholesterol binding CRAC (cholesterol interaction/recognition amino acid consensus) motif at the C-terminal. The CRAC motif of hPLSCR1 interacts with cholesterol with an energy of interaction -64.39 KJ mol

Subjects :: Cholesterol
Membrane Microdomains
Structural Biology
Cell Membrane
Humans
General Medicine
Phospholipid Transfer Proteins
Molecular Biology
Biochemistry

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