Back to Search
Start Over
Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
- Source :
- Diabetes & Metabolism Journal, Vol 44, Iss 1, Pp 186-192 (2020), Diabetes & Metabolism Journal
- Publication Year :
- 2020
- Publisher :
- Korean Diabetes Association, 2020.
-
Abstract
- Renal fibrosis is considered to be the final common outcome of chronic kidney disease. Dipeptidyl peptidase-4 (DPP-4) inhibitors have demonstrated protective effects against diabetic kidney disease. However, the anti-fibrotic effect of evogliptin, a DPP-4 inhibitor, has not been studied. Here, we report the beneficial effects of evogliptin on unilateral ureteral obstruction (UUO)-induced renal fibrosis in mice. Evogliptin attenuated UUO-induced renal atrophy and tubulointerstitial fibrosis. Immunohistochemistry and Western blotting demonstrated that evogliptin treatment inhibits pro-fibrotic gene expressions and extracellular matrix production. In vitro findings showed that the beneficial effects of evogliptin on renal fibrosis are mediated by inhibition of the transforming growth factor-β/Smad3 signaling pathway. The present study demonstrates that evogliptin is protective against UUO-induced renal fibrosis, suggesting that its clinical applications could extend to the treatment of kidney disease of non-diabetic origin.
- Subjects :
- medicine.medical_specialty
Drug/Regimen
Endocrinology, Diabetes and Metabolism
Urology
030209 endocrinology & metabolism
Dipeptidyl peptidase-4 inhibitor
030204 cardiovascular system & hematology
Protective Agents
urologic and male genital diseases
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Piperazines
Kidney Tubules, Proximal
03 medical and health sciences
Mice
kidney failure, chronic
0302 clinical medicine
Diabetes mellitus
Evogliptin
medicine
Renal fibrosis
Animals
Smad3 Protein
Inflammation
transforming growth factor beta
lcsh:RC648-665
biology
business.industry
urogenital system
Brief Report
Transforming growth factor beta
medicine.disease
Fibrosis
Mice, Inbred C57BL
dipeptidyl-peptidase iv inhibitors
biology.protein
Tubulointerstitial fibrosis
Immunohistochemistry
Kidney Diseases
business
medicine.drug
Kidney disease
Signal Transduction
Ureteral Obstruction
Subjects
Details
- Language :
- English
- ISSN :
- 22336087 and 22336079
- Volume :
- 44
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Diabetes & Metabolism Journal
- Accession number :
- edsair.doi.dedup.....6b47b764f8256def1f02a50f82055412