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FAM48A mediates compensatory autophagy induced by proteasome impairment
- Source :
- Genes to cells : devoted to molecularcellular mechanisms. 24(8)
- Publication Year :
- 2019
-
Abstract
- Maintaining protein homeostasis is central to cell survival. The ubiquitin-proteasome system and autophagy play pivotal roles in protein quality control through protein degradation. Activities of these degradative pathways are carefully orchestrated, and autophagy is up-regulated during proteasome dysfunction for cellular homeostasis. However, the mechanism by which proteasome impairment induces compensatory autophagy has remained largely elusive. Here, we show that FAM48A mediates autophagy induction during proteasome inhibition. FAM48A is degraded by the proteasome and accumulates in cells by proteasome inhibition. Knockdown of FAM48A led to defective induction of autophagy during proteasome inhibition and accompanied by defective localization of Atg9 on recycling endosomes. Our results indicate that FAM48A is a kind of sensor that is required for compensatory autophagy induction upon proteasome impairment.
- Subjects :
- Cell Nucleus
0303 health sciences
Gene knockdown
Proteasome Endopeptidase Complex
Proteasome Inhibition
Endosome
Autophagy
Cellular homeostasis
Autophagy-Related Proteins
Cell Biology
Protein degradation
Biology
Immunohistochemistry
Cell biology
Cell Line
Substrate Specificity
03 medical and health sciences
Proteasome
Genetics
Humans
Cell survival
030304 developmental biology
Transcription Factors
Subjects
Details
- ISSN :
- 13652443
- Volume :
- 24
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Genes to cells : devoted to molecularcellular mechanisms
- Accession number :
- edsair.doi.dedup.....6b44ce50bc6c2c74f383d0d081bc4d08