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Aberrant deleted in liver cancer-1 expression is associated with tumor metastasis and poor prognosis in urothelial carcinoma
- Source :
- APMIS. 121:1131-1138
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- This study explored the potential role of deleted in liver cancer-1 (DLC-1) as a prognostic indicator of cancer metastasis and survival in urothelial carcinoma (UC). Tissue microarrays were constructed from paraffin-embedded specimens from 88 UC patients, and immunohistochemical staining was performed to investigate the association of DLC-1 with clinicopathologic characteristics and clinical outcome. The DLC-1 expression showed a significant positive correlation with tumor location (p = 0.041) and a significant negative correlation with advanced histological grade (p = 0.013). In tumors with low DLC-1 expression, Bcl-2 positivity was observed in 24.4% of cases. The DLC-1 expression had significant negative associations with Bcl-2 expression (p = 0.032) and with highly metastatic UC (p = 0.032). Kaplan-Meier analysis showed that DLC-1 protein expression was negatively associated with both overall survival (OS) (p = 0.035) and with distant metastasis-free survival (DMFS) (p = 0.041), but not with disease-free survival. Multivariate analyses indicated that tumor size was the significant independent predictors of OS (p = 0.048); however, only DLC-1 expression was a significant independent predictor of DMFS (p = 0.019). In conclusion, reduced DLC-1 protein expression may be an important factor in tumor progression and a useful prognostic molecular marker in UC.
- Subjects :
- Adult
Male
Microbiology (medical)
Oncology
Urologic Neoplasms
medicine.medical_specialty
Poor prognosis
Cancer metastasis
Kaplan-Meier Estimate
Biology
Disease-Free Survival
Pathology and Forensic Medicine
Metastasis
Young Adult
Internal medicine
Biomarkers, Tumor
medicine
Humans
Immunology and Allergy
Neoplasm Metastasis
Aged
Urothelial carcinoma
Aged, 80 and over
Paraffin Embedding
Tissue microarray
Tumor Suppressor Proteins
GTPase-Activating Proteins
General Medicine
Middle Aged
medicine.disease
Gene Expression Regulation, Neoplastic
Proto-Oncogene Proteins c-bcl-2
Tissue Array Analysis
Tumor progression
Disease Progression
Immunohistochemistry
Female
Urothelium
Liver cancer
Subjects
Details
- ISSN :
- 09034641
- Volume :
- 121
- Database :
- OpenAIRE
- Journal :
- APMIS
- Accession number :
- edsair.doi.dedup.....6b21aed94953745e19d24505791a9bcb