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CT volume measurement for prognostic evaluation of unresectable hepatocellular carcinoma after TACE
- Source :
- World journal of gastroenterology. 16(16)
- Publication Year :
- 2010
-
Abstract
- AIM: To analyze the value of computed tomography (CT) volume measurements for evaluation of the survival rate of unresectable hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). METHODS: One hundred and sixty-six unresectable HCC patients after TACE were involved in this retrospective study. Hepatic CT scan was performed for all patients before and 4 wk to 2 mo after TACE to define the morphologic features of HCC including its largest diameter, volume, product of the greatest axial dimension, tumor to liver volume ratio (TTLVR), and tumor shrinkage ratio. Clinical variables used in the study included gender, age, pattern of tumor growth, number of lesions, Child-Pugh classification of liver function, repeated TACE times, pre- or post-treatment α-fetoprotein (AFP) level, portal vein cancerous thrombus, tumor metastasis, degree of lipiodol retention within the tumor, and percutaneous ethanol injection. The correlation between survival time and clinical variables of patients or lesions was analyzed by combining morphologic features with the corresponding clinical and general data as input. A Cox proportional hazard model was used to analyze prognostic factors. The Kaplan-Meier method was used to calculate the cumulative survival time. Influence of the parameters on prognosis was analyzed by the log-rank test. RESULTS: The overall 6, 12, 24, 36 and 60 mo cumulative survival rates were 78.92%, 49.85%, 23.82%, 15.60% and 8.92%, respectively. The median survival time was 12 mo. Univariate and multivariate analysis showed that only 4 parameters were the independent prognostic factors including TTLVR (χ2 = 14.328, P < 0.001), portal vein cancerous thrombus (χ2 = 5.643, P = 0.018), repeated TACE times (χ2 = 8.746, P = 0.003), and post-treatment serum AFP level (χ2 = 5.416, P = 0.020). When the TTLVR value was less than 70%, the survival time was inversely correlated with the TTLVR value. CONCLUSION: CT volume measurement technique can predict the prognosis of unresectable HCC patients after TACE.
- Subjects :
- Adult
Male
Carcinoma, Hepatocellular
Time Factors
Brief Article
medicine.medical_treatment
Carcinoma
Medicine
Humans
Chemoembolization, Therapeutic
Transcatheter arterial chemoembolization
Survival rate
Aged
Proportional Hazards Models
Retrospective Studies
business.industry
Proportional hazards model
Liver Neoplasms
Gastroenterology
General Medicine
Middle Aged
medicine.disease
Prognosis
digestive system diseases
Treatment Outcome
Hepatocellular carcinoma
Lipiodol
Female
Liver function
Percutaneous ethanol injection
business
Nuclear medicine
Tomography, X-Ray Computed
medicine.drug
Subjects
Details
- ISSN :
- 22192840
- Volume :
- 16
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- World journal of gastroenterology
- Accession number :
- edsair.doi.dedup.....6b1dedb8063077baaeeefac51c36a141