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NIH workshop report on the trans-agency blood–brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface
- Source :
- Fluids and Barriers of the CNS, Fluids and Barriers of the CNS, Vol 14, Iss 1, Pp 1-17 (2017)
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- A trans-agency workshop on the blood–brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Department of Defense, was conducted in Bethesda MD on June 7–8, 2016. The workshop was structured into four sessions: (1) blood sciences; (2) exosome therapeutics; (3) next generation in vitro blood–brain barrier (BBB) models; and (4) BBB delivery and targeting. The first day of the workshop focused on the physiology of the blood and neuro-vascular unit, blood or biofluid-based molecular markers, extracellular vesicles associated with brain injury, and how these entities can be employed to better evaluate injury states and/or deliver therapeutics. The second day of the workshop focused on technical advances in in vitro models, BBB manipulations and nanoparticle-based drug carrier designs, with the goal of improving drug delivery to the central nervous system. The presentations and discussions underscored the role of the BBI in brain injury, as well as the role of the BBB as both a limiting factor and a potential conduit for drug delivery to the brain. At the conclusion of the meeting, the participants discussed challenges and opportunities confronting BBI translational researchers. In particular, the participants recommended using BBI translational research to stimulate advances in diagnostics, as well as targeted delivery approaches for detection and therapy of both brain injury and disease. Electronic supplementary material The online version of this article (doi:10.1186/s12987-017-0061-6) contains supplementary material, which is available to authorized users.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Traumatic brain injury
Drug delivery to the brain
Translational research
Review
Therapeutics
Exosomes
Blood–brain barrier
Extracellular vesicles
lcsh:RC346-429
Translational Research, Biomedical
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Developmental Neuroscience
Internal medicine
medicine
Animals
Humans
Neurodegeneration
Intensive care medicine
lcsh:Neurology. Diseases of the nervous system
Cancer
Brain Diseases
Hematology
business.industry
Biological Transport
General Medicine
Combat casualty
medicine.disease
Magnetic Resonance Imaging
United States
3. Good health
030104 developmental biology
medicine.anatomical_structure
National Institutes of Health (U.S.)
Neurology
Blood-Brain Barrier
business
Delivery
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 20458118
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Fluids and Barriers of the CNS
- Accession number :
- edsair.doi.dedup.....6b1c6befaa7589a36062397083dc5455