Back to Search
Start Over
Improved Efficacy of 10-Day Sequential Treatment for Helicobacter pylori Eradication in Children: A Randomized Trial
- Source :
- Gastroenterology. 129:1414-1419
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Background & Aims: The currently recommended first-line eradication treatment of Helicobacter pylori in children is usually successful in about 75%. Recently, in adults, a novel 10-day sequential treatment has achieved an eradication rate of 95%. The aim of the study was to assess the H pylori eradication rate of the sequential treatment regimen compared with conventional triple therapy in children. Methods: Seventy-eight consecutive children with H pylori infection were randomized to receive either sequential treatment (omeprazole plus amoxicillin for 5 days, followed by omeprazole plus clarithromycin plus tinidazole for another 5 days) (n = 38; 15 boys [39.5%]; median age, 11.0 years [range, 3.3–16 years]) or triple therapy (omeprazole, amoxicillin, and metronidazole) for 1 week (n = 37; 15 boys [40.5%]; median age, 9.9 years [range, 4.3–16 years]). H pylori infection was based on 2 out of 3 positive tests results: 13C-urea breath test, rapid urease test, and histologic analysis. Eradication was assessed by 13C-urea breath test 8 weeks after therapy. Results: Seventy-four patients completed the study. H pylori eradication was achieved in 36 children receiving sequential treatment (97.3%; 95% confidence interval, 86.2–99.5) and 28 children receiving triple therapy (75.7%; 95% confidence interval, 59.8–86.7) (P 95%) in all. Conclusions: Our study shows, for the first time in children, that 10-day sequential treatment achieves a higher eradication rate than standard triple therapy, which is consistent with the results of adult studies.
- Subjects :
- Adult
Male
medicine.medical_specialty
Rapid urease test
Antitrichomonal Agents
Gastroenterology
Tinidazole
Helicobacter Infections
law.invention
Anti-Infective Agents
Randomized controlled trial
law
Clarithromycin
Metronidazole
Internal medicine
Humans
Medicine
Child
Omeprazole
Breath test
Helicobacter pylori
Hepatology
biology
medicine.diagnostic_test
business.industry
Remission Induction
Amoxicillin
Anti-Ulcer Agents
biology.organism_classification
Anti-Bacterial Agents
Regimen
Treatment Outcome
Child, Preschool
Gastritis
Drug Therapy, Combination
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 00165085
- Volume :
- 129
- Database :
- OpenAIRE
- Journal :
- Gastroenterology
- Accession number :
- edsair.doi.dedup.....6b0a32c9102214cbc8807778cd3471ee