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Terlipressin in patients with cirrhosis and type 1 hepatorenal syndrome: a retrospective multicenter study
- Source :
- Scopus-Elsevier
- Publication Year :
- 2002
-
Abstract
- Type 1 hepatorenal syndrome (HRS) is a severe complication of cirrhosis associated with a short median survival time (2 weeks). Although the administration of terlipressin improves renal function, its effect on survival is unknown. This study investigated predictive factors of survival in patients with type 1 HRS treated with terlipressin.Ninety-nine patients with type 1 HRS treated with terlipressin in 24 centers were retrospectively studied. Terlipressin-induced improved renal function was defined as a decrease in serum creatinine value to130 micromol/L or a decrease of at least 20% at the end of treatment.At inclusion, the Child-Pugh score was 11.8 +/- 1.6 (mean +/- SD). Terlipressin (3.2 +/- 1.3 mg/day) was administered for 11 +/- 12 days. Renal function improved in 58% of patients (serum creatinine decreased by 46% +/- 17% from 272 +/- 114 micromol/L). Median survival time was 21 days. Survival rate was 40% at 1 month. Multivariate analysis showed that improved renal function and Child-Pugh scoreor =11 at inclusion were independent predictive factors of survival (P0.0001 and 0.02, respectively). Thirteen patients underwent liver transplantation (92 +/- 95 days after HRS onset), 10 of whom had received terlipressin and had had improved renal function.This retrospective uncontrolled study shows that in patients with type 1 HRS, terlipressin-induced improved renal function is associated with an increase in survival. Thus, a randomized trial investigating the effect of terlipressin on survival in patients with type 1 HRS should be performed.
- Subjects :
- Liver Cirrhosis
Male
medicine.medical_specialty
Cirrhosis
Hepatorenal Syndrome
Lypressin
Gastroenterology
Spontaneous bacterial peritonitis
Hepatorenal syndrome
Internal medicine
medicine
Humans
In patient
Renal Insufficiency
Antihypertensive Agents
Aged
Retrospective Studies
Hepatology
business.industry
Middle Aged
medicine.disease
Survival Analysis
Surgery
Clinical trial
Multivariate Analysis
Female
Terlipressin
business
Complication
Kidney disease
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 00165085
- Volume :
- 122
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Gastroenterology
- Accession number :
- edsair.doi.dedup.....6b000435a0083a6bc6b7a6d2836d5027