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Serum cross-reaction among virulence-associated trimeric autotransporters (VtaA) of Haemophilus parasuis
- Source :
- Veterinary Microbiology. 164:387-391
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Glässer's disease is a fibrinous polyserositis and polyarthritis of swine caused by the bacterium Haemophilus parasuis. Control by vaccination has been limited for years due to lack of cross-protection among strains. However, 6 trimeric autotransporters (VtaA) of the Nagasaki strain were shown to be antigenic and gave partial protection to a lethal challenge. The antigenic relationship among the VtaAs was examined by immunizing mice with individual VtaA showing that they cross-reacted by ELISA mainly with VtaA from the same group. When sera from protected and non-protected vaccinated piglets were examined no differences in VtaA cross-reactivity profiles were found. In addition, sera from commercial pigs immunized with a single VtaA (VtaA9) showed a wider range of VtaA cross-reaction, probably due to the previous colonization by H. parasuis. These results can help the development of new vaccine formulations against H. parasuis by allowing a rational VtaA selection.
- Subjects :
- Haemophilus Infections
Swine
Virulence
Cross Reactions
Biology
Microbiology
Haemophilus parasuis
Mice
Antigen
Haemophilus
Animals
Swine Diseases
Antigens, Bacterial
General Veterinary
Vaccination
Cross reactions
General Medicine
biology.organism_classification
Virology
Immunization
Female
Autotransporters
Subjects
Details
- ISSN :
- 03781135
- Volume :
- 164
- Database :
- OpenAIRE
- Journal :
- Veterinary Microbiology
- Accession number :
- edsair.doi.dedup.....6adc8b78f552c966cfaa626e3703295e