Do Rectal Cancer Patients with PIK3CA Mutations Benefit from Preoperative Radiotherapy with Regard to Local Recurrences?

Preoperative radiation (PRT) significantly reduces local recurrences (LR) in rectal cancer. Identifying patients at risk for LR allows for refinement in patient selection for PRT. We previously demonstrated a PIK3CA mutation prevalence of 7.9% in rectal cancer and a strong association with increased