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A Novel Resistant Maltodextrin Alters Gastrointestinal Tolerance Factors, Fecal Characteristics, and Fecal Microbiota in Healthy Adult Humans
- Source :
- Journal of the American College of Nutrition. 27:356-366
- Publication Year :
- 2008
- Publisher :
- Informa UK Limited, 2008.
-
Abstract
- Resistant maltodextrin has been shown to increase fecal bulk by resisting digestion and being partially fermented by colonic bacteria to short-chain fatty acids (SCFA). The objective of this experiment was to determine potential prebiotic effects, gastrointestinal tolerance, and fecal characteristics of free-living humans fed a novel resistant maltodextrin or a normal maltodextrin control.Subjects (n = 38) were enrolled in a randomized, double-blind study where they were assigned to one of three daily treatments: 15 g maltodextrin; 7.5 g maltodextrin plus 7.5 g resistant maltodextrin (Fibersol-2; Matsutani Chemical Company, Hyogo, Japan); and 15 g resistant maltodextrin. The experiment lasted 7 wk and consisted of a 2 wk baseline period, a 3 wk treatment period, and a 2 wk washout period. During wk 3 to 5 (treatment period), subjects consumed their assigned treatments.Resistant maltodextrin supplementation tended to increase (p = 0.12) fecal Bifidobacterium populations during the treatment period, altered (p0.05) bacterial populations from baseline to treatment, and resulted in very minor effects in gastrointestinal tolerance. There was a shift (p0.05) in molar proportions of SCFA towards butyrate, the preferred energy substrate of colonocytes.Resistant maltodextrin supplementation was well tolerated, resulted in favorable fermentation characteristics in the large bowel, and also resulted in a change in bacterial populations.
- Subjects :
- Adult
DNA, Bacterial
Male
Clostridium perfringens
medicine.medical_treatment
Medicine (miscellaneous)
Polymerase Chain Reaction
Feces
chemistry.chemical_compound
Double-Blind Method
Ammonia
Polysaccharides
RNA, Ribosomal, 16S
medicine
Humans
Food science
Bifidobacterium
Nutrition and Dietetics
biology
Prebiotic
food and beverages
Carbohydrate
Fatty Acids, Volatile
biology.organism_classification
Maltodextrin
Gastrointestinal Tract
Lactobacillus
chemistry
Resistant maltodextrin
Electrophoresis, Polyacrylamide Gel
Female
Fermentation
Digestion
Subjects
Details
- ISSN :
- 15411087 and 07315724
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Nutrition
- Accession number :
- edsair.doi.dedup.....6ad2d61e856fa18365a39fe5c01183c3