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Entosis Controls a Developmental Cell Clearance in C. elegans
- Source :
- Cell reports, Cell Reports, Vol 26, Iss 12, Pp 3212-3220.e4 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- SUMMARY Metazoan cell death mechanisms are diverse and include numerous non-apoptotic programs. One program called entosis involves the invasion of live cells into their neighbors and is known to occur in cancers. Here, we identify a developmental function for entosis: to clear the male-specific linker cell in C. elegans. The linker cell leads migration to shape the gonad and is removed to facilitate fusion of the gonad to the cloaca. We find that the linker cell is cleared in a manner involving cell-cell adhesions and cell-autonomous control of uptake through linker cell actin. Linker cell entosis generates a lobe structure that is deposited at the site of gonad-to-cloaca fusion and is removed during mating. Inhibition of lobe scission inhibits linker cell death, demonstrating that the linker cell invades its host while alive. Our findings demonstrate a developmental function for entosis: to eliminate a migrating cell and facilitate gonad-to-cloaca fusion, which is required for fertility.<br />Graphical Abstract<br />In Brief Entosis is a cell death mechanism, previously observed in cancer cell populations, that involves the invasion of live cells into their neighbors. Lee et al. now show that entosis has a developmental function in C. elegans, clearing the linker cell during gonad formation.
- Subjects :
- 0301 basic medicine
Programmed cell death
Entosis
Uropod
Cell
Cell Communication
Biology
lobe
gonad
General Biochemistry, Genetics and Molecular Biology
Article
Imaging
03 medical and health sciences
cell cannibalism
0302 clinical medicine
medicine
Animals
Cell adhesion
Caenorhabditis elegans
lcsh:QH301-705.5
book
Actin
scission
entosis
urogenital system
uropod
Developmental cell
cell adhesion
3. Good health
Cell biology
entotic cell death
030104 developmental biology
medicine.anatomical_structure
engulfment
lcsh:Biology (General)
book.journal
linker cell death
Linker
030217 neurology & neurosurgery
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Cell reports, Cell Reports, Vol 26, Iss 12, Pp 3212-3220.e4 (2019)
- Accession number :
- edsair.doi.dedup.....6acec57b7b9194898bfe04d5144092f1