Back to Search
Start Over
Use of oral bisphosphonates and risk of hospital admission with osteonecrosis of the jaw: Large prospective cohort study in UK women
- Source :
- 2019, ' Use of oral bisphosphonates and risk of hospital admission with osteonecrosis of the jaw : Large prospective cohort study in UK women ', Bone, vol. 124, pp. 69-74 . https://doi.org/10.1016/j.bone.2019.04.003
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- About 1 in 10 postmenopausal UK women are currently prescribed oral bisphosphonates, but there are concerns about their adverse effects. Osteonecrosis of the jaw is a recognised uncommon but important side effect of intravenous bisphosphonates, but epidemiological evidence on risk of osteonecrosis of the jaw associated with oral bisphosphonate use is less conclusive. The incidence of hospital admission with osteonecrosis of the jaw was examined among 521,695 Million Women Study participants, aged 64.7 years at baseline. Cox proportional hazards regression was used to estimate adjusted relative risks (RRs) and 95% confidence intervals (CIs) associated with use of oral bisphosphonates in postmenopausal women followed-up by record-linkage to National Health Service hospital admission databases. During mean follow-up of 8.2 years per woman, 100 women were admitted to hospital with first recorded osteonecrosis of the jaw, at mean age 72.4 years. Almost a third (29/100) of the cases had ever-used oral bisphosphonates. Ever-users had a six-fold increased risk of hospital admission for osteonecrosis of the jaw, when compared with never-users (adjusted RR = 6.09, 95% CI 3.83-9.66; p 0.0001). The relative risk for osteonecrosis of the jaw in never-users of oral bisphosphonates was increased in women with prior cancer (RR = 3.40, 2.22-5.22, p 0.0001). The estimated absolute risk of hospital admission for osteonecrosis of the jaw over a 5-year period from age 70 to 74 in women without prior cancer was 0.09 per 1000 in never-users and 0.69 per 1000 in ever-users of oral bisphosphonates. In this UK population of postmenopausal women, use of oral bisphosphonates was associated with a 6-fold increased risk of hospital admission with osteonecrosis of the jaw, accounting for around one-third of cases, with an excess risk of about 0.6/1000 users over 5 years.
- Subjects :
- Risk
0301 basic medicine
Million Women Study
medicine.medical_specialty
Histology
Physiology
Endocrinology, Diabetes and Metabolism
Osteoporosis
Population
Administration, Oral
030209 endocrinology & metabolism
MRONJ
03 medical and health sciences
0302 clinical medicine
Risk Factors
Oral bisphosphonate
Internal medicine
Epidemiology
Humans
Medicine
Women
Prospective Studies
Prospective cohort study
education
Aged
education.field_of_study
Osteonecrosis of the jaw
Diphosphonates
business.industry
Absolute risk reduction
Middle Aged
medicine.disease
United Kingdom
Hospitalization
Postmenopause
stomatognathic diseases
030104 developmental biology
Relative risk
Bisphosphonate-Associated Osteonecrosis of the Jaw
Female
SPS Exercise, Nutrition and Health Sciences
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- 2019, ' Use of oral bisphosphonates and risk of hospital admission with osteonecrosis of the jaw : Large prospective cohort study in UK women ', Bone, vol. 124, pp. 69-74 . https://doi.org/10.1016/j.bone.2019.04.003
- Accession number :
- edsair.doi.dedup.....6ace8547f3be9eca6f480f55c7d89839