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An Intracerebral Exploration of Functional Connectivity during Word Production
An Intracerebral Exploration of Functional Connectivity during Word Production
- Source :
- Journal of Computational Neuroscience, Journal of Computational Neuroscience, 2019, 46 (1), pp.125-140. ⟨10.1007/s10827-018-0699-3⟩, Journal of Computational Neuroscience, Springer Verlag, 2019, 46 (1), pp.125-140. ⟨10.1007/s10827-018-0699-3⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- International audience; Language is mediated by pathways connecting distant brain regions that have diverse functional roles. For word production, the network includes a ventral pathway, connecting temporal and inferior frontal regions, and a dorsal pathway, connecting parietal and frontal regions. Despite the importance of word production for scientific and clinical purposes, the functional connectivity underlying this task has received relatively limited attention, and mostly from techniques limited in either spatial or temporal resolution. Here, we exploited data obtained from depth intra-cerebral electrodes stereotactically implanted in eight epileptic patients. The signal was recorded directly from various structures of the neocortex with high spatial and temporal resolution. The neurophysiological activity elicited by a picture naming task was analyzed in the time-frequency domain (10–150 Hz), and functional connectivity between brain areas among ten regions of interest was examined. Task related-activities detected within a network of the regions of interest were consistent with findings in the literature, showing task-evoked desynchronization in the beta band and synchronization in the gamma band. Surprisingly, long-range functional connectivity was not particularly stronger in the beta than in the high-gamma band. The latter revealed meaningful sub-networks involving, notably, the temporal pole and the inferior frontal gyrus (ventral pathway), and parietal regions and inferior frontal gyrus (dorsal pathway). These findings are consistent with the hypothesized network, but were not detected in every patient. Further research will have to explore their robustness with larger samples.
- Subjects :
- Male
0301 basic medicine
repetition
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology
Speech Language
integration
Functional connectivity
0302 clinical medicine
retrieval
Language
Brain Mapping
Neocortex
Temporal pole
[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior
neurobiology
Brain
[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Electroencephalography
dynamics
Middle Aged
Sensory Systems
medicine.anatomical_structure
Dorsal stream
oscillations
Female
Picture naming
Adult
speech production
Cognitive Neuroscience
Models, Neurological
Inferior frontal gyrus
Biology
03 medical and health sciences
Cellular and Molecular Neuroscience
medicine
Humans
Speech
Word production
model
Epilepsy
Neurophysiology
030104 developmental biology
Temporal resolution
Stereo-electroencephalography
Ventral stream
Nerve Net
hippocampal activity
Neuroscience
030217 neurology & neurosurgery
language production
Subjects
Details
- Language :
- English
- ISSN :
- 09295313 and 15736873
- Database :
- OpenAIRE
- Journal :
- Journal of Computational Neuroscience, Journal of Computational Neuroscience, 2019, 46 (1), pp.125-140. ⟨10.1007/s10827-018-0699-3⟩, Journal of Computational Neuroscience, Springer Verlag, 2019, 46 (1), pp.125-140. ⟨10.1007/s10827-018-0699-3⟩
- Accession number :
- edsair.doi.dedup.....6abe579287fec0de96ccad1494aa496b
- Full Text :
- https://doi.org/10.1007/s10827-018-0699-3⟩