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An Intracerebral Exploration of Functional Connectivity during Word Production

An Intracerebral Exploration of Functional Connectivity during Word Production

Authors :
Catherine Liégeois-Chauvel
Amandine Grappe
Pierre Sacré
Jorge Gonzalez-Martinez
Sridevi V. Sarma
F.-Xavier Alario
Johns Hopkins University (JHU)
Institut de Neurosciences des Systèmes (INS)
Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Laboratoire de psychologie cognitive (LPC)
Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
ANR-16-CONV-0002,ILCB,ILCB: Institute of Language Communication and the Brain(2016)
Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
Source :
Journal of Computational Neuroscience, Journal of Computational Neuroscience, 2019, 46 (1), pp.125-140. ⟨10.1007/s10827-018-0699-3⟩, Journal of Computational Neuroscience, Springer Verlag, 2019, 46 (1), pp.125-140. ⟨10.1007/s10827-018-0699-3⟩
Publication Year :
2019
Publisher :
HAL CCSD, 2019.

Abstract

International audience; Language is mediated by pathways connecting distant brain regions that have diverse functional roles. For word production, the network includes a ventral pathway, connecting temporal and inferior frontal regions, and a dorsal pathway, connecting parietal and frontal regions. Despite the importance of word production for scientific and clinical purposes, the functional connectivity underlying this task has received relatively limited attention, and mostly from techniques limited in either spatial or temporal resolution. Here, we exploited data obtained from depth intra-cerebral electrodes stereotactically implanted in eight epileptic patients. The signal was recorded directly from various structures of the neocortex with high spatial and temporal resolution. The neurophysiological activity elicited by a picture naming task was analyzed in the time-frequency domain (10–150 Hz), and functional connectivity between brain areas among ten regions of interest was examined. Task related-activities detected within a network of the regions of interest were consistent with findings in the literature, showing task-evoked desynchronization in the beta band and synchronization in the gamma band. Surprisingly, long-range functional connectivity was not particularly stronger in the beta than in the high-gamma band. The latter revealed meaningful sub-networks involving, notably, the temporal pole and the inferior frontal gyrus (ventral pathway), and parietal regions and inferior frontal gyrus (dorsal pathway). These findings are consistent with the hypothesized network, but were not detected in every patient. Further research will have to explore their robustness with larger samples.

Details

Language :
English
ISSN :
09295313 and 15736873
Database :
OpenAIRE
Journal :
Journal of Computational Neuroscience, Journal of Computational Neuroscience, 2019, 46 (1), pp.125-140. ⟨10.1007/s10827-018-0699-3⟩, Journal of Computational Neuroscience, Springer Verlag, 2019, 46 (1), pp.125-140. ⟨10.1007/s10827-018-0699-3⟩
Accession number :
edsair.doi.dedup.....6abe579287fec0de96ccad1494aa496b
Full Text :
https://doi.org/10.1007/s10827-018-0699-3⟩