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Amantadine: reappraisal of the timeless diamond-target updates and novel therapeutic potentials
- Source :
- Journal of Neural Transmission, Danysz, W, Dekundy, A, Scheschonka, A & Riederer, P 2021, ' Amantadine : reappraisal of the timeless diamond—target updates and novel therapeutic potentials ', Journal of Neural Transmission, vol. 128, no. 2, pp. 127–169 . https://doi.org/10.1007/s00702-021-02306-2
- Publication Year :
- 2020
-
Abstract
- The aim of the current review was to provide a new, in-depth insight into possible pharmacological targets of amantadine to pave the way to extending its therapeutic use to further indications beyond Parkinson’s disease symptoms and viral infections. Considering amantadine’s affinities in vitro and the expected concentration at targets at therapeutic doses in humans, the following primary targets seem to be most plausible: aromatic amino acids decarboxylase, glial-cell derived neurotrophic factor, sigma-1 receptors, phosphodiesterases, and nicotinic receptors. Further three targets could play a role to a lesser extent: NMDA receptors, 5-HT3 receptors, and potassium channels. Based on published clinical studies, traumatic brain injury, fatigue [e.g., in multiple sclerosis (MS)], and chorea in Huntington’s disease should be regarded potential, encouraging indications. Preclinical investigations suggest amantadine’s therapeutic potential in several further indications such as: depression, recovery after spinal cord injury, neuroprotection in MS, and cutaneous pain. Query in the database http://www.clinicaltrials.gov reveals research interest in several further indications: cancer, autism, cocaine abuse, MS, diabetes, attention deficit-hyperactivity disorder, obesity, and schizophrenia.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Neurology
Disease
Bioinformatics
Neuroprotection
Receptors, N-Methyl-D-Aspartate
Neurology and Preclinical Neurological Studies - Review Article
03 medical and health sciences
0302 clinical medicine
Neurotrophic factors
medicine
Amantadine
Humans
Biological Psychiatry
business.industry
Multiple sclerosis
Chorea
Parkinson Disease
medicine.disease
Psychiatry and Mental health
030104 developmental biology
Huntington Disease
Schizophrenia
Neurology (clinical)
medicine.symptom
Diamond
business
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 14351463
- Volume :
- 128
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of neural transmission (Vienna, Austria : 1996)
- Accession number :
- edsair.doi.dedup.....6ab65bbcc6cc67dad8015b0825f35fb2