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External validation of blood eosinophils, FE(NO) and serum periostin as surrogates for sputum eosinophils in asthma
- Source :
- Thorax, 70(2), 115-120. BMJ Publishing Group
- Publication Year :
- 2015
-
Abstract
- Monitoring sputum eosinophils in asthma predicts exacerbations and improves management of asthma. Thus far, blood eosinophils and FE(NO) show contradictory results in predicting eosinophilic airway inflammation. More recently, serum periostin was proposed as a novel biomarker for eosinophilic inflammation. Quantifying the mutual relationships of blood eosinophils, FE(NO), and serum periostin with sputum eosinophils by external validation in two independent cohorts across various severities of asthma. The first cohort consisted of 110 patients with mild to moderate asthma (external validation cohort). The replication cohort consisted of 37 patients with moderate to severe asthma. Both cohorts were evaluated cross-sectionally. Sputum was induced for the assessment of eosinophils. In parallel, blood eosinophil counts, serum periostin concentrations and FENO were assessed. The diagnostic accuracy of these markers to identify eosinophilic asthma (sputum eosinophils ≥3%) was calculated using receiver operating characteristics area under the curve (ROC AUC). In the external validation cohort, ROC AUC for blood eosinophils was 89% (p
- Subjects :
- Pulmonary and Respiratory Medicine
Adult
Male
Sputum Cytology
Periostin
Nitric Oxide
Severity of Illness Index
Leukocyte Count
Eosinophilic
Eosinophilia
Medicine
Humans
Asthma
Inflammation
business.industry
Area under the curve
Sputum
Middle Aged
respiratory system
medicine.disease
respiratory tract diseases
Eosinophils
Cross-Sectional Studies
Breath Tests
ROC Curve
Area Under Curve
Immunology
Cohort
Disease Progression
Biomarker (medicine)
Female
medicine.symptom
business
Cell Adhesion Molecules
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 00406376
- Volume :
- 70
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Thorax
- Accession number :
- edsair.doi.dedup.....6ab5c44b05b6e3e4a3882368c97308d3