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Multiple sclerosis in Belgian children: A multicentre retrospective study
- Source :
- European journal of paediatric neurology
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background: Although the diagnosis of multiple sclerosis (MS) in the paediatric population remains challenging, paediatric-onset MS is increasingly recognized worldwide. Methods: We report on the clinical and biochemical features of a Belgian multicentre cohort of paediatric MS patients in a national retrospective descriptive study. Results: Twenty one paediatric MS patients from four Belgian University Hospitals were included. In nine patients, onset of MS was before the age of ten years which makes the study cohort of special interest. We report a higher incidence "of acute disseminated encephalomyelitis (ADEM)-like first MS attacks and an overall higher proportion of poly symptomatic episodes than in adult and most paediatric cohorts reported in the literature. The clinical presentation in our cohort was rather severe with high median EDSS-score during the first clinical manifestation and barely more than half of our study patients showing full recovery after their first clinical manifestation. Also, a significant proportion of children in our cohort has severe disease progression despite disease modifying therapy and 9.5% of patients showed transition to secondary progressive multiple sclerosis during adolescence. Conclusion: An early and correct diagnosis of paediatric MS is essential to start early adequate treatment. As illustrated by our study cohort, current treatment options in childhood are unsatisfactory. (C) 2016 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Multiple Sclerosis
Optic Neuritis
Adolescent
Disease
03 medical and health sciences
0302 clinical medicine
Belgium
Recurrence
medicine
Humans
Optic neuritis
030212 general & internal medicine
Child
Retrospective Studies
Expanded Disability Status Scale
business.industry
Incidence
Incidence (epidemiology)
Multiple sclerosis
Encephalomyelitis, Acute Disseminated
Retrospective cohort study
General Medicine
Multiple Sclerosis, Chronic Progressive
medicine.disease
Child, Preschool
Pediatrics, Perinatology and Child Health
Immunology
Acute disseminated encephalomyelitis
Cohort
Disease Progression
Female
Human medicine
Neurology (clinical)
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10903798
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- European Journal of Paediatric Neurology
- Accession number :
- edsair.doi.dedup.....6aaf204239d9d8d2fadb194c71858770