Back to Search
Start Over
Coronary microvascular dysfunction is associated with poor glycemic control amongst female diabetics with chest pain and non-obstructive coronary artery disease
- Source :
- Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-12 (2019), Cardiovascular Diabetology
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Background Patients with type 2 diabetes mellitus are at an increased risk of adverse cardiovascular events compared to those without diabetes. The timing, relative to disease onset, and degree of glycemic control that reduces the risk of adverse cardiovascular events remains uncertain. Coronary microvascular dysfunction is prevalent in patients with type 2 diabetes mellitus and is linked to adverse cardiovascular events. We assessed the association between endothelial-dependent and endothelial-independent coronary microvascular dysfunction and glycemic control in patients presenting with chest pain and nonobstructive coronary disease at angiography. Methods Patients presenting with chest pain and found to have non-obstructive CAD (stenosis 140 mg/dL was significantly associated with an abnormal CFRAdn Ratio, 4.28 (1.43–12.81). Conclusion Poor glycemic control is associated with coronary microvascular dysfunction amongst female diabetics presenting with chest pain and non-obstructive CAD. These findings highlight the importance of sex specific risk stratification models and treatment strategies when managing cardiovascular risk amongst diabetics. Further studies are required to identify additional risk prevention tools and therapies targeting microvascular dysfunction as an integrated index of cardiovascular risk. Electronic supplementary material The online version of this article (10.1186/s12933-019-0833-1) contains supplementary material, which is available to authorized users.
- Subjects :
- Blood Glucose
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
Adenosine
Vasodilator Agents
Endocrinology, Diabetes and Metabolism
Coronary Artery Disease
Fractional flow reserve
030204 cardiovascular system & hematology
Coronary Angiography
Chest pain
Coronary artery disease
0302 clinical medicine
Risk Factors
Prevalence
Vasoconstrictor Agents
Original Investigation
Middle Aged
Coronary Vessels
Echocardiography, Doppler
3. Good health
Fractional Flow Reserve, Myocardial
Female
medicine.symptom
Cardiology and Cardiovascular Medicine
Risk assessment
Adult
medicine.medical_specialty
Minnesota
030209 endocrinology & metabolism
Risk Assessment
Angina Pectoris
03 medical and health sciences
Sex Factors
Diabetes mellitus
Internal medicine
medicine
Humans
Hypoglycemic Agents
Aged
Retrospective Studies
Glycemic
Glycated Hemoglobin
business.industry
Microcirculation
Coronary Stenosis
Type 2 Diabetes Mellitus
Retrospective cohort study
medicine.disease
Acetylcholine
Cross-Sectional Studies
Diabetes Mellitus, Type 2
lcsh:RC666-701
Microvessels
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 14752840
- Volume :
- 18
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cardiovascular Diabetology
- Accession number :
- edsair.doi.dedup.....6a88d34d4868f3fd16fdfede5eee9b24