Clinical challenges in a patient with two BRAF V600E-mutated diseases

EW: A 51-year-old Caucasian male smoker (>30 pack-year) was referred due to generalised lymphadenopathy and disseminated, apical accentuated pulmonary nodules (up to 12 mm) on CT scans that demonstrated an elevated 18F-FDG uptake. There was a history of childhood pulmonary tuberculosis with ongoing positivity in the interferon-gamma release assay. The patient had night sweats and frequent coughs. Lymph node and bone marrow biopsies demonstrated infiltration by a small cell lymphocytic lymphoma-Non Hodgkin Lymphoma (SCL-NHL) with chronic lymphocytic leukemia (CLL-like) immunophenotype (Matutes score 4/5) staged as Ann Arbor IV B disease (figure 1A,B). Figure 1 Figure demonstrates results of the pathological and molecular analysis of biopsies from a lymph node (LN) affected by a small cell lymphocytic lymphoma and a pulmonary biopsy (PB) of the same patient affected by a PLCH. (A) HE TCT Thymin-Cytosin-Thymin (DNA base codes); PLCH, pulmonary …