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Role of immune system in tumor progression and carcinogenesis
- Source :
- Journal of cellular biochemistry. 119(7)
- Publication Year :
- 2017
-
Abstract
- Tumor micro-environment has potential to customize the behavior of the immune cell according to their need. In immune-eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and adaptive immune cells synergistically provide shelter as well as fulfill their requirement that helps in progression. In between eliminating and establishment phase, equilibrium and escaping phase regulate the immune cells response. During immune-escaping, (1) the antigenic response generated is either inadequate, or focused entirely on tolerance, and (2) immune response generated is specific and effective, but the tumor skips immune recognition. In this review, we are discussing the critical role of immune cells and their cytokines before and after the establishment of tumor which might play a critical role during immunotherapy.
- Subjects :
- 0301 basic medicine
Carcinogenesis
animal diseases
medicine.medical_treatment
chemical and pharmacologic phenomena
Biology
Biochemistry
Natural killer cell
03 medical and health sciences
0302 clinical medicine
Immune system
Neoplasms
medicine
Animals
Humans
Molecular Biology
Tumor microenvironment
Immunity, Cellular
Innate immune system
Cell Biology
Dendritic cell
Immunotherapy
biochemical phenomena, metabolism, and nutrition
Tumor antigen
030104 developmental biology
medicine.anatomical_structure
Tumor progression
030220 oncology & carcinogenesis
Cancer research
bacteria
Cytokines
Subjects
Details
- ISSN :
- 10974644
- Volume :
- 119
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of cellular biochemistry
- Accession number :
- edsair.doi.dedup.....6a68f749fa8d4add5fbdb1337d49fd8f