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Identification of a constitutively active mutant of the human oxytocin receptor
- Source :
- Scopus-Elsevier, Advances in Experimental Medicine and Biology ISBN: 9781461372103
- Publication Year :
- 1998
-
Abstract
- Oxytocin (OT) and vasopressin (AVP) receptors belong to the G-protein-coupled receptor family; in these receptors, the peptide agonists bind to a region delimited by the upper third of the transmembrane part of the molecule (1) and the molecular interactions responsible for agonist selectivity have been extensively investigated (2–5). However, nothing is known on the intramolecular changes that characterize the active conformation(s) of these receptors. In order to get a better understanding of the process of receptor activation, we started a project aimed at the identification of the key residues involved in stabilizing the active conformation(s) of the human oxytocin receptor.
- Subjects :
- Agonist
Vasopressin
medicine.drug_class
Inositol Phosphates
Oxytocin
Transfection
GTP-Binding Proteins
medicine
Animals
Humans
Point Mutation
Binding site
Receptor
COS cells
Binding Sites
Chemistry
Cell Membrane
GPCRs
computational modeling
molecular simulations
constitutively active mutants
oxytocin receptor
Oxytocin receptor
Transmembrane protein
Recombinant Proteins
Cell biology
Amino Acid Substitution
Receptors, Oxytocin
COS Cells
Mutagenesis, Site-Directed
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- Language :
- English
- ISBN :
- 978-1-4613-7210-3
- ISBNs :
- 9781461372103
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Advances in Experimental Medicine and Biology ISBN: 9781461372103
- Accession number :
- edsair.doi.dedup.....6a63cd789b8abeeecf2307a1da3e8fc6