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Early detection of pulmonary exacerbations in children with Cystic Fibrosis by electronic home monitoring of symptoms and lung function

Authors :
Sanne Vaassen
Bjorn Winkens
Ilja de Vreede
Edward Dompeling
Quirijn Jöbsis
Dillys van Vliet
Karin de Winter-de Groot
Marieke van Horck
Geertjan Wesseling
Kim D G van de Kant
MUMC+: MA Arts Assistenten Kindergeneeskunde (9)
FHML Methodologie & Statistiek
RS: CAPHRI - R6 - Promoting Health & Personalised Care
RS: CAPHRI - R5 - Optimising Patient Care
MUMC+: MA Med Staf Spec Longziekten (9)
Pulmonologie
Promovendi PHPC
Family Medicine
MUMC+: MA Medische Staf Kindergeneeskunde (9)
Kindergeneeskunde
Source :
Scientific Reports, 7(1). Nature Publishing Group, Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017), Scientific Reports, Scientific Reports, 7:12350. Nature Publishing Group
Publication Year :
2017
Publisher :
Nature Publishing Group, 2017.

Abstract

Pulmonary exacerbations (PEx) in Cystic Fibrosis (CF) are associated with an increased morbidity and even mortality. We investigated whether early detection of PEx in children with CF is possible by electronic home monitoring of symptoms and lung function. During this one-year prospective multi-centre study, 49 children with CF were asked to use a home monitor three times a week. Measurements consisted of a respiratory symptom questionnaire and assessment of Forced Expiratory Volume in one second (FEV1). Linear mixed-effects and multiple logistic regression analyses were used. In the 2 weeks before a PEx, the Respiratory Symptom Score (RSS) of the home monitor increased (p = 0.051). The FEV1 as percentage of predicted (FEV1%pred) did not deteriorate in the 4 weeks before a PEx. Nevertheless, the FEV1%pred at the start of exacerbation was significantly lower than the FEV1%pred in the non-exacerbation group (mean difference 16.3%, p = 0.012). The combination of FEV1%pred and RSS had a sensitivity to predict an exacerbation of 92.9% (CI 75.0–98.8%) and a specificity of 88.9% (CI 50.7–99.4%). The combination of home monitor FEV1%pred and RSS can be helpful to predict a PEx in children with CF at an early stage.

Details

Language :
English
ISSN :
20452322
Volume :
7
Database :
OpenAIRE
Journal :
Scientific Reports
Accession number :
edsair.doi.dedup.....6a544ff4805a06f1f1fc39b80bda757c