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Long non-coding RNA SNHG1 regulates zinc finger E-box binding homeobox 1 expression by interacting with TAp63 and promotes cell metastasis and invasion in Lung squamous cell carcinoma
- Source :
- Biomedicine & Pharmacotherapy. 90:650-658
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- The long non-coding RNAs (lncRNAs) have been recently shown to participate in the progression of a variety of cancers. However, the biological role of lncRNAs and the underlying mechanisms in Lung squamous cell carcinoma (SCC) or lung adenocarcinoma (AD) remain unclear. Herein, we investigated expression of 5 lncRNAS (SNHG1, NCBP2-AS2, LINC01206, SOX2-OT and LINC01419) in SCC and AD tissues. SNHG1 was one of over-expressed lncRNAs in SCC tissues. Knockdown of SNHG1 significantly inhibited the proliferation, metastasis, invasive ability and induced apoptosis of SCC cells. Moreover, SNHG1 affected the expression of zinc finger E-box binding homeobox 1(ZEB1), which has also been observed to be up-regulated in SCC and to promote cell metastasis and invasion. Rather than direct interaction, SNHG1 regulated ZEB1expression by suppressing the activity of p63 TA isoform (TAp63), which is a repressor of ZEB1 and physically associates with SNHG1. Furthermore, SNHG1 promoted ZEB1 expression and promoted cell proliferation, metastasis, invasive but inhibited apoptosis of SCC cells via the TAp63/ZEB1 pathway. Taken together, our findings suggested that SNHG1 might play an oncogenic role in SCC through ZEB1 signaling pathway by inhibiting TAp63 and might serve as a valuable prognostic biomarker and therapeutic target for SCC patients.
- Subjects :
- Male
0301 basic medicine
Lung Neoplasms
Cell
Adenocarcinoma of Lung
Apoptosis
Adenocarcinoma
Biology
Metastasis
03 medical and health sciences
0302 clinical medicine
Carcinoma, Non-Small-Cell Lung
Biomarkers, Tumor
medicine
Humans
Neoplasm Invasiveness
Neoplasm Metastasis
Aged
Cell Proliferation
Pharmacology
Zinc finger
Gene knockdown
Cell growth
Tumor Suppressor Proteins
Zinc Finger E-box-Binding Homeobox 1
General Medicine
medicine.disease
Long non-coding RNA
Up-Regulation
Gene Expression Regulation, Neoplastic
stomatognathic diseases
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Cancer research
Female
RNA, Long Noncoding
Signal transduction
Signal Transduction
Transcription Factors
Subjects
Details
- ISSN :
- 07533322
- Volume :
- 90
- Database :
- OpenAIRE
- Journal :
- Biomedicine & Pharmacotherapy
- Accession number :
- edsair.doi.dedup.....6a37b69b1fd89d8e6d63ec0b8b80a8b1