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In vivo intravascular photoacoustic imaging at a high speed of 100 frames per second
- Source :
- Biomed Opt Express
- Publication Year :
- 2020
- Publisher :
- Optical Society of America, 2020.
-
Abstract
- Intravascular photoacoustic (IVPA) imaging technology enables the visualization of pathological characteristics (such as inflammation activities, lipid deposition) of the artery wall. Blood flushing is a necessary step in improving the imaging quality in in vivo IVPA imaging. But the limited imaging speed of the systems stretches their flushing time, which is an important obstacle of their clinical translations. In this paper, we report an improvement in IVPA/IVUS imaging speed to 100 frames per second. The high-speed imaging is demonstrated in rabbit in vivo, visualizing the nanoparticles accumulated on abdominal aorta wall at the wavelength of 1064 nm, in real time display. Blood flushing in vivo improves the IVPA signal-noise-ratio by around 3.5 dB. This study offers a stable, efficient and easy-to-use tool for instantaneous disease visualization and disease diagnosis in research and forwards IVPA/IVUS imaging technology towards clinical translations.
- Subjects :
- 0303 health sciences
Materials science
medicine.diagnostic_test
Photoacoustic imaging in biomedicine
Image processing
Frame rate
01 natural sciences
Atomic and Molecular Physics, and Optics
Article
010309 optics
03 medical and health sciences
Optical coherence tomography
In vivo
Imaging quality
0103 physical sciences
medicine
Imaging technology
Preclinical imaging
030304 developmental biology
Biotechnology
Biomedical engineering
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Biomed Opt Express
- Accession number :
- edsair.doi.dedup.....6a2a0a361b443ce93c860942b65cb02d