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Individualized tumor response testing profile has a prognostic value in childhood acute leukemias: multicenter non-interventional long-term follow-up study
- Source :
- Leukemia & Lymphoma. 54:1256-1262
- Publication Year :
- 2012
- Publisher :
- Informa UK Limited, 2012.
-
Abstract
- A total number of 817 children with acute lymphoblastic leukemia (ALL) and 181 with acute myeloblastic leukemia (AML) were assessed for individualized tumor response testing (ITRT) profile as a prognostic factor in long-term follow-up. For each patient, ITRT, initial response to therapy and long-term outcome were assessed. In initial ALL, an impact on long-term response was shown in ITRT for 13 drugs, while in initial AML only for cytarabine. For patients with ALL, a combined five-drug ITRT profile for prednisolone, l-asparaginase, vincristine, cytarabine and daunorubicin or doxorubicin had predictive value for probability of disease-free survival (pDFS) in univariate analysis, whereas in multivariate analysis, bone marrow response by day 33 was the only prognostic factor. For patients with AML, no factor had prognostic value for pDFS in univariate analysis, while ITRT to cytarabine almost reached significance. In conclusion, ITRT can possibly be regarded as a risk factor in childhood acute leukemias.
- Subjects :
- Oncology
Cancer Research
Vincristine
medicine.medical_specialty
Adolescent
Acute myeloblastic leukemia
Daunorubicin
Young Adult
Risk Factors
hemic and lymphatic diseases
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Risk factor
Child
Univariate analysis
business.industry
Infant, Newborn
Myeloid leukemia
Hematology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prognosis
medicine.disease
Leukemia, Myeloid, Acute
Treatment Outcome
Drug Resistance, Neoplasm
Child, Preschool
Immunology
Prednisolone
Cytarabine
business
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....6a1ef049cf31904388861dc0f9a338c7