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Alphaherpesviruses and the Cytoskeleton in Neuronal Infections

Authors :
Sofia Zaichick
Gregory A. Smith
Kevin P. Bohannon
Source :
Viruses, Viruses, Vol 3, Iss 7, Pp 941-981 (2011)
Publication Year :
2011
Publisher :
MDPI AG, 2011.

Abstract

Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. Neuroinvasion typically requires efficient viral transmission through a polarized epithelium followed by long-distance transport through the viscous axoplasm. These events are mediated by the recruitment of the cellular microtubule motor proteins to the intracellular viral particle and by alterations to the cytoskeletal architecture. The focus of this review is the interplay between neurotropic herpesviruses and the cytoskeleton.

Details

ISSN :
19994915
Volume :
3
Database :
OpenAIRE
Journal :
Viruses
Accession number :
edsair.doi.dedup.....6a1c5037479118ffc0b4dfdff0cfb8ea
Full Text :
https://doi.org/10.3390/v3070941