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Alphaherpesviruses and the Cytoskeleton in Neuronal Infections
- Source :
- Viruses, Viruses, Vol 3, Iss 7, Pp 941-981 (2011)
- Publication Year :
- 2011
- Publisher :
- MDPI AG, 2011.
-
Abstract
- Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. Neuroinvasion typically requires efficient viral transmission through a polarized epithelium followed by long-distance transport through the viscous axoplasm. These events are mediated by the recruitment of the cellular microtubule motor proteins to the intracellular viral particle and by alterations to the cytoskeletal architecture. The focus of this review is the interplay between neurotropic herpesviruses and the cytoskeleton.
- Subjects :
- viruses
lcsh:QR1-502
Review
Alphaherpesvirinae
Biology
lcsh:Microbiology
neuroinvasion
Motor protein
03 medical and health sciences
Microtubule
Virology
medicine
Animals
Humans
virus transport
Cytoskeleton
030304 developmental biology
Neurons
0303 health sciences
030306 microbiology
Peripheral Nervous System Diseases
cytoskeleton
Herpesviridae Infections
Epithelium
3. Good health
Cell biology
Infectious Diseases
medicine.anatomical_structure
Axoplasm
Peripheral nervous system
Free nerve ending
Intracellular
alphaherpesvirus
Subjects
Details
- ISSN :
- 19994915
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....6a1c5037479118ffc0b4dfdff0cfb8ea
- Full Text :
- https://doi.org/10.3390/v3070941