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The effects of protein kinase C (PKC) on the tension of normal and passively sensitized human airway smooth muscle and the activity of voltage-dependent delayed rectifier potassium channel (Kv)
- Source :
- Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 27(2)
- Publication Year :
- 2006
-
Abstract
- The effects of protein kinase C (PKC) on the tension and the activity of voltage-dependent delayed rectifier potassium channel (Ky) were examined in normal and passively sensitized human airway smooth muscle (HASM), by measuring tones and whole-cell patch clamp techniques, and the Kv activities and membrane potential (E m) were also detected. The results showed that phorbol 12-myristate 13-acetate (PMA), a PKC activator, caused a concentration-dependent constriction in normal HASM rings. The constriction of the passively sensitized muscle in asthma serum group was significantly higher than that of the normal group (P
- Subjects :
- Adult
Male
medicine.medical_specialty
Patch-Clamp Techniques
Myocytes, Smooth Muscle
Biomedical Engineering
Bronchi
Biochemistry
Biomaterials
chemistry.chemical_compound
Nifedipine
Internal medicine
Genetics
medicine
Humans
Patch clamp
Protein kinase C
Cells, Cultured
Protein Kinase C
Earth-Surface Processes
Membrane potential
Chemistry
Activator (genetics)
Calcium channel
Muscle, Smooth
Middle Aged
Potassium channel
Asthma
Endocrinology
Phorbol
Female
medicine.drug
Delayed Rectifier Potassium Channels
Subjects
Details
- ISSN :
- 16720733
- Volume :
- 27
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban
- Accession number :
- edsair.doi.dedup.....6a1671d7fd8171b34e92d9eadcda7ed9