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Identification of patients with primary ovarian insufficiency caused by autoimmunity
- Source :
- Reproductive biomedicine online. 35(4)
- Publication Year :
- 2016
-
Abstract
- Autoimmune pathogenesis is responsible for a subset of primary ovarian insufficiency (POI) cases. The significance of autoantibodies for POI, however, remains unclear. A total of 250 women with idiopathic POI and 256 age-matched healthy women were enrolled. The presence in serum of adrenal cortex autoantibody (AAA), detected by indirect immunofluorescence and non-organ-specific antibodies, including antinuclear antibody, anti-cardiolipin antibody, and anti-double stranded DNA antibody, detected by enzyme-linked immunosorbent assay, was compared. Ovarian biopsy was carried out for histology assessment. Adrenal function was followed-up in 15 women with POI who were positive for AAA. Higher frequency of positive AAA was observed in women with POI (19.2%) compared with controls (5.9%, P < 0.01). No difference in anti-cardiolipin antibody, antinuclear antibody and anti-double stranded DNA antibody was found between the two groups. Ovarian biopsies in 13 women with POI (six AAA positive and seven negative) showed atrophic ovaries devoid of follicles. One out of fifteen women positive for AAA had symptoms of adrenal insufficiency 3 years after POI diagnosis. Significantly higher positive frequency of AAA in POI patients suggests the role of autoimmune disturbance in pathogenesis. Therefore, AAA may serve as a biomarker for ovarian autoimmunity.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Anti-nuclear antibody
Biopsy
Ovary
Autoimmunity
Enzyme-Linked Immunosorbent Assay
Primary Ovarian Insufficiency
medicine.disease_cause
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Adrenal insufficiency
Humans
Autoantibodies
030219 obstetrics & reproductive medicine
biology
medicine.diagnostic_test
business.industry
Autoantibody
Obstetrics and Gynecology
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Reproductive Medicine
Immunology
biology.protein
Biomarker (medicine)
Female
Antibody
business
Developmental Biology
Subjects
Details
- ISSN :
- 14726491
- Volume :
- 35
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Reproductive biomedicine online
- Accession number :
- edsair.doi.dedup.....6a14bb8cceeff5fab08a6bb1c857a881