Back to Search
Start Over
Paeoniflorin Atttenuates Amyloidogenesis and the Inflammatory Responses in a Transgenic Mouse Model of Alzheimer's Disease
- Source :
- Neurochemical research. 40(8)
- Publication Year :
- 2014
-
Abstract
- Alzheimer's disease (AD) is associated with the inflammatory response in response to amyloid β-peptide (Aβ). Previous studies have suggested that paeoniflorin (PF) shows anti-inflammatory and neuroprotective effects in inflammation-related diseases. However, the impacts of PF on AD have not been investigated. In the present study, we showed that a 4-week treatment with PF could significantly inhibit Aβ burden, Aβ-induced over activation of astrocytes and microglia, downregulation of proinflammatory cytokines, and upregulation of anti-inflammatory cytokines in the brain. In addition, we demonstrated that chronic treatment with PF inhibited the activation of glycogen synthase kinase 3β (GSK-3β) and reversed neuroinflammtory-induced activation of nuclear factor-kappa B (NF-κB) signaling pathways. Moreover, PF exerted inhibitory effects on NALP3 inflammasome, caspase-1, and IL-1β. Collectively, in the present study, we demonstrated that PF exhibits neuroprotective effects in amyloid precursor protein (APP) and presenilin 1 (PS1) double-transgenic (APP/PS1) mice via inhibiting neuroinflammation mediated by the GSK-3β and NF-κB signaling pathways and nucleotide-binding domain-like receptor protein 3 inflammasome. Thus, these results suggest that PF might be useful to intervene in development or progression of neurodegeneration in AD through its anti-inflammatory and anti-amyloidogenic effects.
- Subjects :
- Male
NALP3
Mice, Transgenic
Plaque, Amyloid
Pharmacology
Paeonia
Biochemistry
Neuroprotection
Presenilin
Proinflammatory cytokine
Cellular and Molecular Neuroscience
Amyloid beta-Protein Precursor
Mice
Glucosides
GSK-3
Alzheimer Disease
medicine
Amyloid precursor protein
Presenilin-1
Animals
Neuroinflammation
Inflammation
Memory Disorders
biology
business.industry
Inflammasome
General Medicine
Disease Models, Animal
Immunology
biology.protein
Monoterpenes
Inflammation Mediators
business
medicine.drug
Subjects
Details
- ISSN :
- 15736903
- Volume :
- 40
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Neurochemical research
- Accession number :
- edsair.doi.dedup.....6a0a645e783bc19a79cff7eb9c549096