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Frequency and functional translation of low muscle mass in overweight and obese patients with COPD
- Source :
- Respiratory Research, Vol 22, Iss 1, Pp 1-8 (2021), Respiratory Research, Respiratory Research, 22(1):93. BioMed Central Ltd
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background Cut offs for fat-free mass index (FFMI) and appendicular skeletal muscle mass index (ASMI) are available for diagnosing low muscle mass in patients with COPD. This study aimed to investigate: (1) the frequency of low muscle mass (FFMI and ASMI) applying different cut-offs and (2) the functional translation (clinical impact) of low muscle mass, in patients with COPD stratified into BMI categories. Methods Patients with COPD were assessed regarding body composition, exercise capacity, quadriceps muscle strength, symptoms of anxiety and depression, dyspnea and quality of life upon referral to pulmonary rehabilitation. The proportion of patients with low muscle mass was compared among BMI categories. Clinical outcomes between patients with normal and low muscle mass within each BMI category were compared. Results 469 patients with COPD were included for analyses. The frequency of patients classified as low FFMI varied significantly according to the choice of cut-off (32 to 54%; P Conclusions Approximately half of the overweight and obese patients with COPD have low muscle mass when applying age-gender-BMI-specific cut-offs. Low muscle mass is associated with worse functional outcomes in overweight and obese COPD patients.
- Subjects :
- Male
Quality of life
medicine.medical_specialty
Sarcopenia
medicine.medical_treatment
Overweight
Pulmonary function testing
Body Mass Index
Quadriceps Muscle
03 medical and health sciences
Pulmonary Disease, Chronic Obstructive
0302 clinical medicine
Exercise tolerance
Internal medicine
medicine
Prevalence
Humans
Mass index
Pulmonary rehabilitation
030212 general & internal medicine
Prospective Studies
Obesity
Lung
Aged
Netherlands
lcsh:RC705-779
COPD
business.industry
Research
lcsh:Diseases of the respiratory system
Middle Aged
medicine.disease
Functional Status
030228 respiratory system
Body Composition
Female
medicine.symptom
business
Subjects
Details
- Language :
- English
- ISSN :
- 14659921
- Volume :
- 22
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Respiratory Research
- Accession number :
- edsair.doi.dedup.....69fa0963ec79711bce20a5850b213147