Ligand-Controlled Regiodivergent Hydroformylation of Ynamides: A Stereospecific and Regioselective Access to 2- and 3-Aminoacroleins

International audience; The rhodium-catalyzed hydroformylation of ynamides is described and give selectively access to 2-or 3-aminoacrolein derivatives. The regioselectivity of this carbonylation can be completely controlled at will thanks to the nature of the ligand used. This represent the first example of regiodivergent alkyne hy-droformylation. The influence of the substituents on the differ-ent positions of the ynamide has been investigated and it ap-peared that this reaction is tolerant to a wide range of functional groups