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KDM3A is not associated with metastasis and prognosis of breast cancer
- Source :
- Oncology letters. 15(6)
- Publication Year :
- 2017
-
Abstract
- Lysine demethylase 3A (KDM3A), also known as JMJD1A, has been associated with metastasis and poor prognosis in several cancer types, including renal cell carcinoma, prostate cancer and Ewing sarcoma. However, little is known regarding the clinicopathological significance of KDM3A expression in breast cancer (BCa). To investigate the clinical relevance of KDM3A expression in the setting of BCa, immunohistochemistry was performed on a tissue microarray consisting of 150 commercially available BCa samples. No significant correlation was identified between KDM3A expression and various clinicopathological variables, including clinical stage, pathological grade, tumor size and the expression statuses of human epidermal growth factor receptor 2, estrogen receptor, and progesterone receptor. In addition, no significant association between KDM3A expression and overall prognosis was observed. Taken together, these findings suggest that there is no significant association between KDM3A expression and clinicopathological variables, indicating that KDM3A may not be associated with the malignant behavior of BCa.
- Subjects :
- 0301 basic medicine
Cancer Research
Tissue microarray
business.industry
Estrogen receptor
Cancer
medicine.disease
Lysine demethylase 3A
Metastasis
03 medical and health sciences
Prostate cancer
030104 developmental biology
0302 clinical medicine
Breast cancer
Oncology
030220 oncology & carcinogenesis
medicine
Cancer research
Sarcoma
skin and connective tissue diseases
business
Subjects
Details
- ISSN :
- 17921074
- Volume :
- 15
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Oncology letters
- Accession number :
- edsair.doi.dedup.....69f5794eba2d642d4201142f4b83b0d8