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Toxic effects of sarin in rats at three months following single or repeated low-level inhalation exposure
- Source :
- Pharmacologytoxicology. 88(4)
- Publication Year :
- 2001
-
Abstract
- Male albino Wistar rats were once or repeatedly exposed to three various low concentrations of sarin for 60 min. in the inhalation chamber. The clinical status of control as well as sarin-poisoned rats was tested 3 months after exposure to sarin using biochemical, haematological, neurophysiological, behavioural and immunotoxicological methods. While biochemical and haematological parameters, including the activities of cholinesterases in erythrocytes, plasma and various organs (brain, diaphragm), did not differ from the control values regardless of the sarin concentration used, few signs of sarin-induced neurotoxicity and immunotoxicity in sarin-poisoned rats were demonstrated. This was especially true when the single exposure of rats to non-convulsive symptomatic concentration and repeated exposure of rats to clinically asymptomatic concentration of sarin was used. In rats repeatedly poisoned with clinically asymptomatic concentrations of sarin, the alteration of the gait characterized by ataxia, the increase in the stereotyped behaviour, the increase in the excitability of the central nervous system following the administration of the convulsive drug pentamethylenetetrazol were observed. In rats poisoned with non-convulsive symptomatic concentration of sarin, the subtle supression of spontaneous, as well as lipopolysaccharides-stimulated, proliferation of spleen lymphocytes and the bactericidal activity of peritoneal macrophages was primarily observed besides the signs of neurotoxicity. Our findings confirm that both non-convulsive symptomatic and clinically asymptomatic concentrations of sarin can only cause very few, subtle long-term signs of neurotoxicity and immunotoxicity in sarin-poisoned rats when the rats were exposed to asymptomatic sarin concentrations repeatedly.
- Subjects :
- Male
Sarin
Ataxia
Health, Toxicology and Mutagenesis
Physiology
Clinical Chemistry Tests
Toxicology
Lymphocyte Activation
Asymptomatic
chemistry.chemical_compound
Central Nervous System Diseases
Seizures
Administration, Inhalation
Toxicity Tests
medicine
Animals
Lymphocytes
Rats, Wistar
Pharmacology
Inhalation exposure
Inhalation Exposure
Hematologic Tests
Inhalation
Behavior, Animal
Chemistry
Neurotoxicity
medicine.disease
Rats
Stereotypy (non-human)
Anesthesia
Immune System
Toxicity
Macrophages, Peritoneal
Cholinesterase Inhibitors
medicine.symptom
Biomarkers
Subjects
Details
- ISSN :
- 09019928
- Volume :
- 88
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Pharmacologytoxicology
- Accession number :
- edsair.doi.dedup.....69dc7425b7b8a97ebcacd0bc398e28ff