Back to Search
Start Over
Role of endoscopic treatment or balloon-occluded retrograde transvenous obliteration in patients with Child-Pugh class C end-stage liver cirrhosis and esophageal/gastric varices
- Source :
- Clinical and Molecular Hepatology, Vol 25, Iss 2, Pp 181-182 (2019), Clinical and Molecular Hepatology
- Publication Year :
- 2019
- Publisher :
- Korean Association for the Study of the Liver, 2019.
-
Abstract
- Background/Aims There is a controversy about the availability of invasive treatment for esophageal/gastric varices in patients with Child-Pugh class C (CP-C) end-stage liver cirrhosis (LC). We have evaluated the validity of invasive treatment with CP-C end-stage LC patients. Methods The study enrolled 51 patients with CP-C end-stage LC who had undergone invasive treatment. The treatment modalities included endoscopic variceal ligation in 22 patients, endoscopic injection sclerotherapy in 17 patients, and balloon-occluded retrograde transvenous obliteration (BRTO) in 12 patients. We have investigated the overall survival (OS) rates and risk factors that contributed to death within one year after treatment. Results The OS rate in all patients at one, three, and five years was 72.6%, 30.2%, and 15.1%, respectively. The OS rate in patients who received endoscopic treatment and the BRTO group at one, three, and five years was 67.6%, 28.2% and 14.1% and 90.0%, 36.0% and 18.0%, respectively. The average of Child-Pugh scores (CPS) from before treatment to one month after variceal treatment significantly improved from 10.53 to 10.02 (P=0.003). Three significant factors that contributed to death within one year after treatment included the presence of bleeding varices, high CPS (≥11), and high serum total bilirubin levels (≥4.0 mg/dL). Conclusions The study demonstrated that patients with a CPS of up to 10 and less than 4.0 mg/dL of serum total bilirubin levels may not have a negative impact on prognosis after invasive treatment for esophageal/gastric varices despite their CP-C end-stage LC.
- Subjects :
- medicine.medical_specialty
Cirrhosis
Esophageal and gastric varices
Balloon
Hemostasis, endoscopic
Humans
Medicine
In patient
Stage (cooking)
lcsh:RC799-869
Portal hypertension
Molecular Biology
Hepatology
medicine.diagnostic_test
business.industry
Endoscopy
Interventional radiology
medicine.disease
Surgery
Radiology, interventional
Balloon occlusion
Hemostasis
Liver cirrhosis
Original Article
Child-Pugh Class C
lcsh:Diseases of the digestive system. Gastroenterology
Gastrointestinal Hemorrhage
business
Subjects
Details
- Language :
- English
- ISSN :
- 22872728
- Volume :
- 25
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical and Molecular Hepatology
- Accession number :
- edsair.doi.dedup.....69cde671f503e938d746e3b0bc9ce05a