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Cocktail of reactive species generated by cold atmospheric plasma : oral administration induces non-small cell lung cancer cell death
- Source :
- Journal of physics: D: applied physics
- Publication Year :
- 2021
-
Abstract
- Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with 85% of all lung cancer reported as NSCLC. Moreover, there are no effective treatments in advanced NSCLC. This study shows for the first time that oral administration of plasma-treated water (PTW) can cure advanced NSCLC. The cold plasma in water generates a cocktail of reactive species, and oral administration of this cocktail to mice showed no toxicities even at the highest dose of PTW, after a single dose and repeated doses for 28 d in mice. In vivo studies reveal that PTW showed favorable anticancer effects on chemo-resistant lung cancer, similarly to gefitinib treatment as a reference drug in a chemo-resistant NSCLC model. The anticancer activities of PTW seem to be involved in inhibiting proliferation and angiogenesis and enhancing apoptosis in the cancer cells. Interestingly, the PTW contributes to enhanced immune response and improved cachexia in the model.
- Subjects :
- Acoustics and Ultrasonics
business.industry
Physics
Atmospheric-pressure plasma
Condensed Matter Physics
medicine.disease
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
respiratory tract diseases
Lung cancer cell
Oral administration
Cancer research
medicine
Non small cell
Lung cancer
business
neoplasms
Subjects
Details
- Language :
- English
- ISSN :
- 00223727
- Database :
- OpenAIRE
- Journal :
- Journal of physics: D: applied physics
- Accession number :
- edsair.doi.dedup.....69cc1876ead7b23e8fe0d2fcacab0f4f