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Human parechovirus type 6 and Guillain-Barré syndrome: a case report
- Source :
- Journal of NeuroVirology. 24:656-659
- Publication Year :
- 2018
- Publisher :
- Springer Science and Business Media LLC, 2018.
-
Abstract
- A previously healthy 6-year-old boy was admitted to hospital with hypotonia and hyposthenia of lower limbs. Electromyography and slow motor nerve conduction velocity test identified a lower limb acute motor axonal neuropathy. Brain and spinal cord magnetic resonance imaging demonstrated multifocal cortical gray matter lesions in both cerebral hemispheres consistent with gray matter acute disseminated encephalitis otherwise with viral/Mycoplasma pneumoniae encephalitis, and signs of involvement of anterior nerve roots of the cauda equina consistent with Guillain-Barré syndrome. The patient resulted negative to routinely bacterial and viral investigations but positive to human parechovirus that sequence analyses confirmed as type 6. Intravenous immunoglobulins and methylprednisolone treatment were administered but did not relieve the symptoms of Guillain-Barré syndrome. The disease improved gradually over the next 3-month follow-up with a complete remission of both central and peripheral nervous system symptoms.
- Subjects :
- Male
0301 basic medicine
Pathology
medicine.medical_specialty
Nerve root
030106 microbiology
Parechovirus
Guillain-Barre Syndrome
Acute motor axonal neuropathy
03 medical and health sciences
Cellular and Molecular Neuroscience
Virology
Acute flaccid paralysis surveillance
Guillain-Barré syndrome
Human parechovirus
Molecular characterization
Neurology
Neurology (clinical)
medicine
Humans
Child
Picornaviridae Infections
Guillain-Barre syndrome
business.industry
Cauda equina
medicine.disease
Hypotonia
medicine.anatomical_structure
Peripheral nervous system
medicine.symptom
business
Encephalitis
Subjects
Details
- ISSN :
- 15382443 and 13550284
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Journal of NeuroVirology
- Accession number :
- edsair.doi.dedup.....69c9bb776003467a65130e09dfcdd5a7