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Gender and age effects on risk factor-based prediction of coronary artery calcium in symptomatic patients: A Euro-CCAD study
- Source :
- Atherosclerosis, 252, 32-39. Elsevier Ireland Ltd, Europe PubMed Central, Nicoll, R, Wiklund, U, Zhao, Y, Diederichsen, A, Mickley, H, Ovrehus, K, Zamorano, J, Gueret, P, Schmermund, A, Maffei, E, Cademartiri, F, Budoff, M & Henein, M 2016, ' Gender and age effects on risk factor-based prediction of coronary artery calcium in symptomatic patients : A Euro-CCAD study ', Atherosclerosis, vol. 252, pp. 32-39 . https://doi.org/10.1016/j.atherosclerosis.2016.07.906
- Publication Year :
- 2016
- Publisher :
- Elsevier Ireland Ltd, 2016.
-
Abstract
- BACKGROUND AND AIMS: The influence of gender and age on risk factor prediction of coronary artery calcification (CAC) in symptomatic patients is unclear.METHODS: From the European Calcific Coronary Artery Disease (EURO-CCAD) cohort, we retrospectively investigated 6309 symptomatic patients, 62% male, from Denmark, France, Germany, Italy, Spain and USA. All of them underwent risk factor assessment and CT scanning for CAC scoring.RESULTS: The prevalence of CAC among females was lower than among males in all age groups. Using multivariate logistic regression, age, dyslipidaemia, hypertension, diabetes and smoking were independently predictive of CAC presence in both genders. In addition to a progressive increase in CAC with age, the most important predictors of CAC presence were dyslipidaemia and diabetes (β = 0.64 and 0.63, respectively) in males and diabetes (β = 1.08) followed by smoking (β = 0.68) in females; these same risk factors were also important in predicting increasing CAC scores. There was no difference in the predictive ability of diabetes, hypertension and dyslipidaemia in either gender for CAC presence in patients aged 70, only dyslipidaemia predicted CAC presence in males and only smoking and diabetes were predictive in females.CONCLUSIONS: In symptomatic patients, there are significant differences in the ability of conventional risk factors to predict CAC presence between genders and between patients aged
- Subjects :
- Adult
Male
medicine.medical_specialty
Multivariate analysis
endocrine system diseases
Coronary Artery Disease
030204 cardiovascular system & hematology
Age and gender
Coronary artery disease
Diabetes Complications
03 medical and health sciences
0302 clinical medicine
Sex Factors
Calcinosis
Predictive Value of Tests
Internal medicine
medicine
Journal Article
Prevalence
Humans
030212 general & internal medicine
cardiovascular diseases
Risk factor
Aged
Dyslipidemias
Retrospective Studies
business.industry
Smoking
Age Factors
nutritional and metabolic diseases
Retrospective cohort study
Middle Aged
medicine.disease
Surgery
Europe
Predictive value of tests
Coronary artery calcification
Hypertension
Multivariate Analysis
Cardiology
cardiovascular system
population characteristics
Female
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 18791484 and 00219150
- Volume :
- 252
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis
- Accession number :
- edsair.doi.dedup.....69c91741e1763509d169e0a649dad1de