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P42 Ebp1 functions as a tumor suppressor in non-small cell lung cancer
- Source :
- BMB REPORTS(48): 3, BMB Reports
- Publication Year :
- 2015
- Publisher :
- Korean Society for Biochemistry and Molecular Biology - BMB Reports, 2015.
-
Abstract
- Although the short isoform of ErbB3-binding protein 1 (Ebp1), p42 has been considered to be a potent tumor suppressor in a number of human cancers, whether p42 suppresses tumorigenesis of lung cancer cells has never been clarified. In the current study we investigated the tumor suppressor role of p42 in non-small cell lung cancer cells. Our data suggest that the expression level of p42 is inversely correlated with the cancerous properties of NSCLC cells and that ectopic expression of p42 is sufficient to inhibit cell proliferation, anchorage-independent growth, and invasion as well as tumor growth in vivo. Interestingly, p42 suppresses Akt activation and overexpression of a constitutively active form of Akt restores the tumorigenic activity of A549 cells that is ablated by exogenous p42 expression. Thus, we propose that p42 Ebp1 functions as a potent tumor suppressor of NSCLC through interruption of Akt signaling. [BMB Reports 2015; 48(3): 159-165]
- Subjects :
- endocrine system
Lung Neoplasms
EGFR
Apoptosis
Biology
medicine.disease_cause
environment and public health
Biochemistry
Non-small cell lung cancer
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
medicine
Humans
Genes, Tumor Suppressor
Lung cancer
Molecular Biology
Protein kinase B
Adaptor Proteins, Signal Transducing
A549 cell
Cell growth
AKT
RNA-Binding Proteins
Tumor suppressor
General Medicine
medicine.disease
Cell biology
ErbB Receptors
enzymes and coenzymes (carbohydrates)
Cell culture
Ebp1
Research-Article
Ectopic expression
biological phenomena, cell phenomena, and immunity
Signal transduction
Carcinogenesis
hormones, hormone substitutes, and hormone antagonists
Signal Transduction
Subjects
Details
- ISSN :
- 19766696
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- BMB Reports
- Accession number :
- edsair.doi.dedup.....69c4bb08d8cd68ec4077826f5d088057