Back to Search
Start Over
Pharmacokinetics of free catecholestrogens and catecholestrogen benzoates
- Source :
- Steroids. 39(3)
- Publication Year :
- 1982
-
Abstract
- To provide a definite basis for studies on the biological effects of exogenously administered catecholestrogens, the time courses of the concentrations of these estrogens in serum, pituitary and CNS-tissues were studied in male rats after s.c. injection of either 150 microgram of 4-hydroxyestradiol or 2-hydroxyestradiol (dissolved in 200 microliter sesame oil/ethanol/ascorbic acid; 97.5/2.5/0.1; vol/vol/wt) or equimolar amounts of 4-hydroxyestradiol 3, 4-dibenzoate or 2-hydroxyestradiol 2,3-dibenzoate (dissolved in 200 microliter sesame oil). The injection of free catecholestrogens resulted in bolus-like elevations of the serum and tissue concentrations of the respective compound (max. values up to 9 ng/ml, half-life below 1 h) whereas the injection of catecholestrogen benzoates gave lower (max. values about 1 ng/ml) but prolonged elevations (half-life approx. 24 h and 32 h for 4-OHE2 and 2-OHE2) of the respective free catecholestrogen.
- Subjects :
- Pharmacology
Male
Ethanol
Tissue concentrations
Chromatography
Time Factors
Organic Chemistry
Clinical Biochemistry
Rats, Inbred Strains
Ascorbic acid
Biochemistry
Benzoates
Estrogens, Catechol
Rats
chemistry.chemical_compound
Kinetics
Endocrinology
chemistry
Pharmacokinetics
Pituitary Gland
Male rats
Animals
Sesame oil
Molecular Biology
Subjects
Details
- ISSN :
- 0039128X
- Volume :
- 39
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Steroids
- Accession number :
- edsair.doi.dedup.....69c4716376cbcd000e8aaae3ee0f440c