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A Comparative Study of Sibship Tests of Linkage and/or Association
- Source :
- The American Journal of Human Genetics. 63:1507-1516
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- SummaryPopulation-based tests of association have used data from either case-control studies or studies based on trios (affected child and parents). Case-control studies are more prone to false-positive results caused by inappropriate controls, which can occur if, for example, there is population admixture or stratification. An advantage of family-based tests is that cases and controls are well matched, but parental data may not always be available, especially for late-onset diseases. Three recent family-based tests of association and linkage utilize unaffected siblings as surrogates for untyped parents. In this paper, we propose an extension of one of these tests. We describe and compare the four tests in the context of a complex disease for both biallelic and multiallelic markers, as well as for sibships of different sizes. We also examine the consequences of having some parental data in the sample.
- Subjects :
- Genetic Markers
Parents
Linkage disequilibrium
Genetic Linkage
Population
Context (language use)
Disease
Biology
Nuclear Family
Association
Family-based tests
Genetics
False Positive Reactions
Genetics(clinical)
education
Nuclear family
Alleles
Genetics (clinical)
Linkage (software)
education.field_of_study
Models, Statistical
Models, Genetic
Transmission/disequilibrium test
Linkage
Genetic Diseases, Inborn
Case-control study
Transmission disequilibrium test
Research Design
Case-Control Studies
Power study
Monte Carlo Method
Research Article
Demography
Subjects
Details
- ISSN :
- 00029297
- Volume :
- 63
- Database :
- OpenAIRE
- Journal :
- The American Journal of Human Genetics
- Accession number :
- edsair.doi.dedup.....69b39451726c1222784f3e347adf39de