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Grading of MRI-detected skull-base invasion in nasopharyngeal carcinoma and its prognostic value
- Source :
- Head & Neck. 33:1309-1314
- Publication Year :
- 2010
- Publisher :
- Wiley, 2010.
-
Abstract
- Background. Our aim was to grade MRI–detected skull-base invasion in nasopharyngeal carcinoma and evaluate the prognostic value of the grading. Methods. The MRI scans and medical records of 924 patients with histologically diagnosed nondisseminated nasopharyngeal carcinoma were reviewed retrospectively. Results. MRI-detected skull-base invasion was not found to be an independent prognostic factor for overall survival, distant metastasis-free survival, or local relapse-free survival (p > .05 for all). Grading of skull-base erosion according to the site of invasion was found to be an independent prognostic factor for both overall survival (p = .003 and p = .006, respectively) and distant metastasis-free survival (p = .001 for both) in the 512 patients with skull-base invasions and 315 patients with T3 disease. Conclusions. MRI-detected skull-base invasion is not an independent prognostic factor for nasopharyngeal carcinoma. However, grading according to the site of invasion as either low grade or severe has prognostic value. © 2010 Wiley Periodicals, Inc. Head Neck, 2010
- Subjects :
- Adult
Gadolinium DTPA
Male
Oncology
medicine.medical_specialty
Adolescent
Nasopharyngeal neoplasm
Contrast Media
Kaplan-Meier Estimate
Young Adult
Internal medicine
Carcinoma
medicine
Humans
Neoplasm Invasiveness
Child
Grading (tumors)
Aged
Retrospective Studies
Skull Base
Neoplasm Grading
medicine.diagnostic_test
business.industry
Medical record
Nasopharyngeal Neoplasms
Magnetic resonance imaging
Retrospective cohort study
Middle Aged
Prognosis
medicine.disease
Magnetic Resonance Imaging
Otorhinolaryngology
Nasopharyngeal carcinoma
Multivariate Analysis
Female
business
Subjects
Details
- ISSN :
- 10433074
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Head & Neck
- Accession number :
- edsair.doi.dedup.....69a5d66e7ea9d4f1e76c25ed6f173b67