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Quantitative MRI Analyses of Regional Brain Growth in Living Fetuses with Down Syndrome
- Source :
- Cereb Cortex
- Publication Year :
- 2019
- Publisher :
- Oxford University Press (OUP), 2019.
-
Abstract
- Down syndrome (DS) is the most common liveborn autosomal chromosomal anomaly and is a major cause of developmental disability. Atypical brain development and the resulting intellectual disability originate during the fetal period. Perinatal interventions to correct such aberrant development are on the horizon in preclinical studies. However, we lack tools to sensitively measure aberrant structural brain development in living human fetuses with DS. In this study, we aimed to develop safe and precise neuroimaging measures to monitor fetal brain development in DS. We measured growth patterns of regional brain structures in 10 fetal brains with DS (29.1 ± 4.2, weeks of gestation, mean ± SD, range 21.7~35.1) and 12 control fetuses (25.2 ± 5.0, range 18.6~33.3) using regional volumetric analysis of fetal brain MRI. All cases with DS had confirmed karyotypes. We performed non-linear regression models to compare fitted regional growth curves between DS and controls. We found decreased growth trajectories of the cortical plate (P = 0.033), the subcortical parenchyma (P = 0.010), and the cerebellar hemispheres (P
- Subjects :
- Down syndrome
Pathology
medicine.medical_specialty
Brain development
Cognitive Neuroscience
Gestational Age
Fetal Development
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Neuroimaging
Prenatal Diagnosis
Intellectual disability
Parenchyma
medicine
Humans
030304 developmental biology
Brain Mapping
0303 health sciences
Fetus
business.industry
Brain
medicine.disease
Magnetic Resonance Imaging
Brain growth
Gestation
Original Article
Down Syndrome
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14602199 and 10473211
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Cerebral Cortex
- Accession number :
- edsair.doi.dedup.....69a4e1067b6354501a0c67576e977269