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Host immune transcriptional profiles reflect the variability in clinical disease manifestations in patients with Staphylococcus aureus infections
- Source :
- PLoS ONE, Vol 7, Iss 4, p e34390 (2012), PLoS ONE
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- Staphylococcus aureus infections are associated with diverse clinical manifestations leading to significant morbidity and mortality. To define the role of the host response in the clinical manifestations of the disease, we characterized whole blood transcriptional profiles of children hospitalized with community-acquired S. aureus infection and phenotyped the bacterial strains isolated. The overall transcriptional response to S. aureus infection was characterized by over-expression of innate immunity and hematopoiesis related genes and under-expression of genes related to adaptive immunity. We assessed individual profiles using modular fingerprints combined with the molecular distance to health (MDTH), a numerical score of transcriptional perturbation as compared to healthy controls. We observed significant heterogeneity in the host signatures and MDTH, as they were influenced by the type of clinical presentation, the extent of bacterial dissemination, and time of blood sampling in the course of the infection, but not by the bacterial isolate. System analysis approaches provide a new understanding of disease pathogenesis and the relation/interaction between host response and clinical disease manifestations.
- Subjects :
- Male
Bacterial Diseases
Microarrays
lcsh:Medicine
Disease
Adaptive Immunity
medicine.disease_cause
0302 clinical medicine
030212 general & internal medicine
Child
lcsh:Science
Immune Response
Oligonucleotide Array Sequence Analysis
Staphylococci
0303 health sciences
Multidisciplinary
Systems Biology
Blood Proteins
Staphylococcal Infections
Acquired immune system
Innate Immunity
Bacterial Pathogens
3. Good health
Community-Acquired Infections
Host-Pathogen Interaction
Infectious Diseases
Staphylococcus aureus
Child, Preschool
Host-Pathogen Interactions
Medicine
Female
Research Article
Adolescent
Staph Infections
Immunology
Biology
Staphylococcal infections
Microbiology
03 medical and health sciences
Immune system
Immunity
medicine
Humans
Staphylococcal Infection
030304 developmental biology
Inflammation
Innate immune system
Gene Expression Profiling
lcsh:R
Infant
Computational Biology
Immune Defense
medicine.disease
Immunity, Innate
Case-Control Studies
lcsh:Q
Biomarkers
Blood sampling
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....69928b40f20f063627ea6e713fff0e85