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Reconstruction of parietal bone defects with adiposederived mesenchymal stem cells. Experimental study
- Source :
- Acta Cirurgica Brasileira, Vol 35, Iss 12 (2021), Acta Cirúrgica Brasileira v.35 n.12 2020, Acta Cirúrgica Brasileira, Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC), instacron:SBDPC, Acta Cirúrgica Brasileira, Volume: 35, Issue: 12, Article number: e351201, Published: 20 JAN 2021
- Publication Year :
- 2021
- Publisher :
- Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2021.
-
Abstract
- Purpose: This study assessed the regeneration potential of mesenchymal stem cells (MSC) from adipose tissue associated with platelet-rich plasma (PRP) in bone regeneration. Methods: Thirty Wistar rats (Rattus norvegicus albinos) were divided into five groups (according to the grafting material and time to euthanasia): (1) autograft - 14 days (control), (2) autograft - 28 days (control), (3) MSC + PRP - 14 days, (4) MSC + PRP + papaverine - 14 days and (5) MSC + PRP + papaverine - 28 days. After euthanasia, the graft was removed and histological slides were prepared. They were assessed by a blinded pathologist using a previously published histological scale as parameter. Results: There was some degree of neoformed bone trabeculae (NBT) in 93.3% of the samples, as well as osteoblastic activity (OA). The autograft groups (14 and 28 days) had higher levels in the formation of bone trabeculae. Nonparametric data were analyzed using the Wilcoxon-Mann-Whitney test and proved not to be statistically significant at p < 0.05. Conclusions: Experimental parietal bone reconstruction, combining MSC, PRP and papaverine presented regeneration in all groups with no significant difference among them.
- Subjects :
- Pathology
medicine.medical_specialty
Bone Regeneration
RD1-811
Adipose tissue
Parietal Bone
03 medical and health sciences
0302 clinical medicine
Animals
Medicine
Rats, Wistar
Bone regeneration
Papaverine
Tissue Engineering
business.industry
Platelet-Rich Plasma
Regeneration (biology)
Mesenchymal stem cell
Mesenchymal Stem Cells
Rats
medicine.anatomical_structure
030220 oncology & carcinogenesis
Platelet-rich plasma
Bone Trabeculae
Original Article
030211 gastroenterology & hepatology
Surgery
business
Parietal bone
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 01028650
- Volume :
- 35
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Acta Cirurgica Brasileira
- Accession number :
- edsair.doi.dedup.....699093c74e6d78c065777d9a16a71b2f